Loratidine

Cat. No. 1944

Loratidine C22H23ClN2O2 [79794-75-5]

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Alternative Name: SCH 29851

Chemical Name: 4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic acid ethyl ester

Biological Activity

Peripheral histamine H1 receptor antagonist (Ki = 35 nM); devoid of central effects. Orally active antiallergic agent.

Technical Data

M.Wt:
382.88
Formula:
C22H23ClN2O2
Solubility:
Soluble to 25 mM in DMSO and to 100 mM in ethanol
Purity:
>99 %
Storage:
Store at RT
CAS No:
79794-75-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Kreutner et al (1987) Antiallergic activity of loratidine, a non-sedating antihistamine. Allergy 42 57. PMID: 2436504.

Ahn and Barnett (1986) Selective displacement of [3H]mepyramine from peripheral vs. central nervous system receptors by loratadine, a non-sedating antihistamine. Eur.J.Pharmacol. 127 153. PMID: 2875889.

Barnett et al (1984) Evaluation of the CNS properties of SCH 29851, a potential non-sedating antihistamine. Agents Actions 14 590. PMID: 6236679.

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Keywords: Loratidine, supplier, Peripheral, H1, antagonists, anti-allergic, agent, Receptors, Histamine, histaminergic, SCH29851, Tocris Bioscience, Histamine H1 Receptor Antagonist products

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