Cat. No. 3010
Biological ActivityProtease-activated receptor 2 (PAR2) agonist (Ki = 9.64 μM and IC50 = 10.4 μM). Corresponds to the tethered ligand exposed by trypsin cleavage of PAR-2. Control peptide VKGILS-NH2 also available (Cat. No. 3392).
(Modifications: Val-6 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Kanke et al (2005) Binding of a highly potent protease-activated receptor-2 (PAR2) activating peptide, [3H]2-furoyl-LIGRL-NH2, to human PAR2. Br.J.Pharmacol. 145 255. PMID: 15765104.
Hollenberg and Compton (2002) International union of pharmacology XXVIII. Proteinase-activated receptors. Pharmacol.Rev. 54 203. PMID: 12037136.
Bohm et al (1996) Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2. Biochem.J. 314 1009. PMID: 8615752.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for SLIGKV-NH2 include:
Namkung et al (2016) Monitoring G protein-coupled receptor and [beta]-arrestin trafficking in live cells using enhanced bystander BRET Nature Communications 7 12178. PMID: 27397672.
Do you know of a great paper that uses SLIGKV-NH2 from Tocris? If so please let us know.
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Keywords: SLIGKV-NH2, supplier, PAR2, receptor, agonists, Receptors, Protease-Activated, proteinase-activated, Tocris Bioscience, Protease-Activated Receptor Agonist products
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