Cat. No. 2640
Chemical Name: N,N-Dimethyl-5-[(5-methyl-1,1-dioxo
Biological Activity5-HT1D receptor agonist that displays selectivity over other 5-HT receptor subtypes (pIC50 values are 7.2, 6.1, < 5.0 and < 5.0 for 5-HT1D, 5-HT1A, 5-HT2A and 5-HT3 respectively) and other receptors (pIC50 < 5.0 for adenosine, adrenergic, excitatory amino acids, dopamine, histamine, muscarinic, nicotinic and opiate receptors).
Licensing InformationSold with the permission of Merck, Sharpe and Dohme Ltd.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Castro et al (1994) Synthesis and biological activity of 3-[2-(dimethylamino)ethyl]-5-[(1,1-dioxo-5-methyl-1,2,5-thiadiazolidin-2-yl)-methyl]-1H-indole and analogues: agonists for the 5-HT1D receptor. J.Med.Chem. 37 3023. PMID: 7932524.
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Keywords: L-703,664 succinate, supplier, Selective, 5-HT1D, receptor, agonists, Serotonin, Receptors, L703664, Tocris Bioscience, 5-HT1D Receptor Agonist products
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