Cat. No. 2768
Chemical Name: N-(5-Chloro-2-methoxyphenyl)-N'-(2-m
Biological ActivityInsulin-like growth factor receptor (IGF1R) inhibitor. Suppresses IGF-stimulated IGF-IR autophosphorylation with an IC50 value of 12 μM. Inhibits growth of MCF-7 breast cancer cells in vitro and in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Sivakumar et al (2009) Autocrine loop for IGF-I receptor signaling in SLUG-mediated epithelial-mesenchymal transition. 34 329. PMID: 19148466.
Anderson et al (2006) Parallel synthesis of diarylureas and their evaluation as inhibitors of insulin-like growth factor receptor. J.Comb.Chem. 8 784. PMID: 16961415.
Gable et al (2006) Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth. Mol.Cancer 5 1079.
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Citations are publications that use Tocris products. Selected citations for PQ 401 include:
Ilatovskaya et al (2013) Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli. Am J Physiol Cell Physiol 305 C1050. PMID: 24048730.
Shen et al (2012) Insulin-like growth factor (IGF) binding protein 2 functions coordinately with receptor protein tyrosine phosphatase β and the IGF-I receptor to regulate IGF-I-stimulated signaling. Mol Cell Biol 32 4116. PMID: 22869525.
Jameson et al (2011) Activation of the insulin-like growth factor-1 receptor induces resistance to epidermal growth factor receptor antagonism in head and neck squamous carcinoma cells. Mol Cancer Ther 10 2124. PMID: 21878657.
Sanchez-Alavez et al (2011) Insulin-like growth factor 1-mediated hyperthermia involves anterior hypothalamic insulin receptors. J Biol Chem 286 14983. PMID: 21330367.
Radhakrishnan et al (2010) Insulin-like growth factor-I-stimulated insulin receptor substrate-1 negatively regulates Src homology 2 domain-containing protein-tyrosine phosphatase substrate-1 function in vascular smooth muscle cells. J Biol Chem 285 15682. PMID: 20207740.
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Keywords: PQ 401, supplier, IGF-IR, inhibitors, inhibits, Receptors, Insulin-like, Receptor, Tyrosine, Kinases, RTKs, PQ401, Tocris Bioscience, Insulin and Insulin-like Receptors Inhibitor products
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