Cat. No. 1941
Chemical Name: 2,4,6-Trimethyl-N-[3-(trifluorometh
Biological ActivityActivator of phospholipase C (PLC). Stimulates superoxide generation, Ca2+ release and inositol phosphate formation in a variety of cell types. Also inhibits growth of the leukemic cell lines U937 and THP-1. Inactive control o-3M3FBS (Cat. No. 1942) available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Lee et al (2005) The novel phospholipase C activator, m-3M3FBS, induces monocytic leukemia cell apoptosis. Cancer Lett. 222 227. PMID: 15863272.
Krjukova et al (2004) Phospholipase C activator m-3M3FBS affects Ca2+ homeostasis independently of phospholipase C activation. Br.J.Pharmacol. 143 3. PMID: 15302681.
Bae et al (2003) Identification of a compound that directly stimulates phospholipase C activity. Mol.Pharmacol. 63 1043. PMID: 12695532.
If you know of a relevant reference for m-3M3FBS please let us know.
Citations are publications that use Tocris products. Selected citations for m-3M3FBS include:
Rioult-Pedotti et al (2015) Dopamine Promotes Motor Cortex Plasticity and Motor Skill Learning via PLC Activation. J Gen Physiol 10 e0124986. PMID: 25938462.
Shambharkar et al (2015) TMEM203 Is a Novel Regulator of Intracellular Calcium Homeostasis and Is Required for Spermatogenesis. PLoS One 10 e0127480. PMID: 25996873.
Semple-Rowland et al (2014) Activation of phospholipase C mimics the phase shifting effects of light on melatonin rhythms in retinal photoreceptors. PLoS One 8 e83378. PMID: 24386190.
Hutchins et al (2013) Calcium release-dependent actin flow in the leading process mediates axophilic migration. PLoS One 33 11361. PMID: 23843509.
Krjukova et al (2004) Phospholipase C activator m-3M3FBS affects Ca2+ homeostasis independently of phospholipase C activation. Br J Pharmacol 143 3. PMID: 15302681.
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Keywords: m-3M3FBS, supplier, Phospholipases, C, activators, activates, PLC, esterases, Tocris Bioscience, Phospholipase Activator products