Cat. No. 1937
Chemical Name: 1H-Pyrazolo[3,4-b]quinoxalin-3-amin
Biological ActivityInhibitor of cyclin-dependent kinases (cdks) and glycogen synthase kinase-3 (GSK-3). IC50 values are 0.6, 0.4 and 1 μM for cdk1/cyclin B, cdk5/p25 and GSK-3 respectively.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Ortega et al (2002) Pyrazolo[3,4-b]quinoxalines. A new class of cyclin-dependent kinases inhibitors. Bioorg.Med.Chem.Lett. 10 2177. PMID: 11983514.
Monge et al (1995) 3-Amino-2-quinoxalinecarbonitrile. New fused quinoxalines with potential cytotoxic activity. J.Heterocycl.Chem. 31 1135.
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Keywords: NSC 693868, supplier, GSK-3, inhibitors, inhibits, cdks, GSK, Glycogen, Synthase, Kinases, 3, Cyclin-Dependent, Protein, Carbohydrate, Metabolism, NSC693868, Tocris Bioscience, Cyclin-Dependent Protein Kinase Inhibitor products
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