Damnacanthal

Cat. No. 1936

Damnacanthal C16H10O5 [477-84-9]

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Chemical Name: 9,10-Dihydroxy-3-hydroxy-1-methoxy-9,10-dioxo-2-anthracenecarboxaldehyde

Biological Activity

Potent inhibitor of p56lck tyrosine kinase activity (IC50 = 17 nM for inhibition of autophosphorylation). Displays 7- to 20-fold selectivity over p59fyn and p60src tyrosine kinases, > 40-fold selectivity over c-ErbB2, EGF- and insulin-receptor tyrosine kinases, and > 100-fold selectivity over PKA and PKC. Mobilizes intracellular Ca2+ in dermal fibroblasts and inhibits Ras function. Also inhibits LIMK1/2, as well as migration and invasion of breast cancer cells in vitro.

Technical Data

M.Wt:
282.25
Formula:
C16H10O5
Solubility:
Soluble to 25 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
477-84-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Aoki et al (2000) Mechanism of damnacanthal-induced [Ca2+]i elevation in human dermal fibroblasts. Eur.J.Pharmacol. 387 119. PMID: 10650151.

Faltynek et al (1995) Damnacanthal is a highly potent, selective inhibitor fo p56lck tyrosine kinase activity. Biochemistry 34 12404. PMID: 7547985.

Hiramatsu et al (1993) Induction of normal phenotypes in ras-transformed cells by damnacanthal from Morinda citrifolia. Cancer Lett. 73 161. PMID: 7693328.

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Keywords: Damnacanthal, supplier, potent, inhibitors, inhibits, p56lck, kinases, selective, Tocris Bioscience, Src Kinase Inhibitor products

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