Cat. No. 1935
Chemical Name: N-[3-(3,4-Dihydroxyphenyl)-1-oxo-2-
Biological ActivityPhosphopeptide ligand for the src SH2 domain (IC50 = 42 nM); displays 30-fold higher affinity than N-acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu (Ac-pYEEIE, Cat. No. 1927).
(Modifications: Tyr-1 = N-[3-(3,4-Dihydroxyphenyl)-1-o
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
on-line. Please contact Customer Service
Park et al (2002) Design and characterization of non-phosphopeptide inhibitors for src family SH2 domains. Bioorg.Med.Chem.Lett. 12 2711. PMID: 12217360.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for Caffeic acid-pYEEIE include:
Xie et al (2015) A selective NMR probe to monitor the conformational transition from inactive to active kinase. J Neurosci 10 262. PMID: 25248068.
Do you know of a great paper that uses Caffeic acid-pYEEIE from Tocris? If so please let us know.
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Keywords: Caffeic acid-pYEEIE, supplier, Phosphopeptide, ligands, src, SH2, domain, Kinases, Tocris Bioscience, Src Kinase Ligand products
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