Melanocyte-stimulating hormone release inhibiting factor

Cat. No. 1929

Melanocyte-stimulating hormone release inhibiting factor Pro-Leu-Gly-NH2

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Alternative Names: Pro-Leu-Gly amide, MIF-I, PLG

Biological Activity

Inhibitor of melanocyte-stimulating hormone (MSH) release. Blocks the release of α-MSH, increases brain dopamine levels and antagonizes physiological and behavioral opioid effects in vivo.

Technical Data


(Modifications: Gly-3 = C-terminal amide)

Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Kavaliers and Hirst (1986) Inhibitory influences of FMRFamide and PLG on stress-induced opioid analgesia and activity. Brain Res. 372 370. PMID: 2871903.

Mishra et al (1983) Pharmacology of L-Prolyl-L-Leucyl-Glycinamide (PLG): a review. Methods Find.Exp.Clin.Pharmacol. 5 203. PMID: 6136640.

Pugsley and Lippmann (1977) Synthetic melanocyte stimulating hormone release inhibiting factor (MIF). Part III: effect of L-prolyl-N-methyl-D-leucyl-glycinamide and MIF on biogenic amine turnover. Arzneimittelforschung 27 2293. PMID: 23796.

Plotnikoff and Kastin (1974) Pharmacological studies with a tripeptide, Prolyl-Leucyl Glycine amide. Arch.Int.Pharmacodyn.Ther. 211 211. PMID: 4156639.

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Keywords: Melanocyte-stimulating hormone release inhibiting factor, supplier, α-MSH, alpha-MSH, a-MSH, release, inhibits, inhibitors, melanocortin, receptors, Tocris Bioscience, Melanocortin (MC) Receptor products

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