Cat. No. 1927
Chemical Name: N-Acetyl-O-phosphono-L-tyrosyl-L-α-g
Biological ActivityPhosphopeptide ligand for the src SH2 domain (IC50 = 1 μM). Blocks src interactions with EGFR and FAK.
(Modifications: Tyr-1 = pTyr with C-terminal Ac)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Park et al (2002) Design and characterization of non-phosphopeptide inhibitors for src family SH2 domains. Bioorg.Med.Chem.Lett. 12 2711. PMID: 12217360.
Pacofsky et al (1998) Potent dipeptide inhibitors of the pp60c-src SH2 domain. J.Med.Chem. 41 1894. PMID: 9599239.
Gilmer et al (1994) Peptide inhibitors of src SH3-SH2-phosphoprotein interactions. J.Biol.Chem. 269 31711. PMID: 7527393.
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Keywords: N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu, supplier, Phosphopeptide, ligands, SH2, domain, Src, Kinases, Tocris Bioscience, Src Kinase Ligand products
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