Cat. No. 1922
Biological ActivityAntagonist at the ghrelin receptor (GHS-R1a) (IC50 = 0.9 μM). Also weakly binds to melanocortin receptors (Ki = 26-120 μM). Centrally active in vivo.
(Modifications: Trp-2 = D-Trp, Lys-3 = D-Lys, Phe-5 = D-Phe, Lys-6 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Pinilla et al (2003) Role of ghrelin in the control of growth hormone secretion in prepubertal rats: interactions with excitatory amino acids. Neuroendocrinology 77 83. PMID: 12624529.
Traebert et al (2002) Ghrelin acts on leptin-responsive neurones in the rat arcuate nucleus. J.Neuroendocrinol. 14 580. PMID: 12121496.
Schioth et al (1997) Characterization of the binding of MSH-B, HP-228, GHRP-6 and 153N-6 to the human melanocortin receptor subtypes. Neuropeptides 31 565. PMID: 9574823.
If you know of a relevant reference for [D-Lys3]-GHRP-6 please let us know.
Citations are publications that use Tocris products. Selected citations for [D-Lys3]-GHRP-6 include:
Gomez and (2014) The effects of ghrelin antagonists [D-Lys(3) ]-GHRP-6 or JMV2959 on ethanol, water, and food intake in C57BL/6J mice. Alcohol Clin Exp Res 38 2436. PMID: 25257292.
Kemp et al (2011) Intrarenal ghrelin infusion stimulates distal nephron-dependent sodium reabsorption in normal rats. PLoS Comput Biol 57 633. PMID: 21220707.
Do you know of a great paper that uses [D-Lys3]-GHRP-6 from Tocris? If so please let us know.
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Keywords: [D-Lys3]-GHRP-6, supplier, Ghrelin, receptors, antagonists, GHS-R1a, Growth, Hormone, Secretagog, 1a, Tocris Bioscience, Ghrelin Receptor Antagonist products
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