[D-Phe12]-Bombesin

Cat. No. 1913

[D-Phe12]-Bombesin Glp-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-D-Phe-Leu-Met-NH2

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Biological Activity

Bombesin receptor antagonist; inhibits bombesin-induced amylase release in guinea pig pancreas (IC50 = 4 mM). Centrally active in vivo.

Technical Data

M.Wt:
1629.9
Formula:
C74H112N22O18S
Sequence:
XQRLGNQWAVGFLM

(Modifications: X = Glp, Phe-12 = D-Phe, Gly-14 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
108437-87-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Merali et al (1988) (D-Phe12) Bombesin and substance P analogues function as central bombesin receptor antagonists. Synapse 2 282. PMID: 2463692.

Moody et al (1988) Localization of receptors for bombesin-like peptides in the rat brain. Ann.N.Y.Acad.Sci. 547 114. PMID: 2853589.

Heinz-Erian et al (1987) [D-Phe12]Bombesin analogues: a new class of bombesin receptor antagonists. Am.J.Physiol. 252 G439. PMID: 2435173.

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Keywords: [D-Phe12]-Bombesin, supplier, Bombesin, receptor, antagonists, GRP-Preferring, Receptors, BB1-3, Gastrin-Releasing, Peptide-Preferring, NMB-Preferring, Neuromedin, B-Preferring, Tocris Bioscience, Bombesin Receptor Antagonist products

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