Neuromedin N (rat, mouse, porcine, canine)
Cat. No. 1907
Biological ActivityEndogenous neurotensin-like neuropeptide, originally isolated from porcine spinal cord. Binds to neurotensin receptors (IC50 = 16.7 nM for inhibition of [Trp11]-NT binding to rat brain receptors). Regulates guinea pig intestinal smooth muscle contraction and produces hypotension in rats. Also induces hypothermia following central administration in rats in vivo.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Dubuc et al (1988) Hypothermic effect of neuromedin N in mice and its potentiation by peptidase inhibitors. Eur.J.Pharmacol. 151 117. PMID: 3416919.
Checler et al (1986) Neuromedin N: high affinity interaction with neurotensin receptors and rapid inactivation by brain synaptic peptidases. Eur.J.Pharmacol. 126 239. PMID: 3019713.
Minamino et al (1984) Neuromedin N: a novel neurotensin-like peptide identified in porcine spinal cord. Biochem.Biophys.Res.Commun. 122 542. PMID: 6547840.
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Keywords: Neuromedin N, supplier, Neurotensin-like, peptide, NT, Receptors, Neurotensin, agonists, NeuromedinN, Tocris Bioscience, Neurotensin Receptor Agonist products
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