Neuromedin N (rat, mouse, porcine, canine)

Cat. No. 1907

Neuromedin N Lys-Ile-Pro-Tyr-Ile-Leu

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Biological Activity

Endogenous neurotensin-like neuropeptide, originally isolated from porcine spinal cord. Binds to neurotensin receptors (IC50 = 16.7 nM for inhibition of [Trp11]-NT binding to rat brain receptors). Regulates guinea pig intestinal smooth muscle contraction and produces hypotension in rats. Also induces hypothermia following central administration in rats in vivo.

Technical Data

M.Wt:
745.96
Formula:
C38H63N7O8
Sequence:
KIPYIL
Solubility:
Soluble to 0.50 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
92169-45-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Dubuc et al (1988) Hypothermic effect of neuromedin N in mice and its potentiation by peptidase inhibitors. Eur.J.Pharmacol. 151 117. PMID: 3416919.

Checler et al (1986) Neuromedin N: high affinity interaction with neurotensin receptors and rapid inactivation by brain synaptic peptidases. Eur.J.Pharmacol. 126 239. PMID: 3019713.

Minamino et al (1984) Neuromedin N: a novel neurotensin-like peptide identified in porcine spinal cord. Biochem.Biophys.Res.Commun. 122 542. PMID: 6547840.

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Citations are publications that use Tocris products.

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Keywords: Neuromedin N, supplier, Neurotensin-like, peptide, NT, Receptors, Neurotensin, agonists, NeuromedinN, Tocris Bioscience, Neurotensin Receptor Agonist products

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