Sarafotoxin S6a

Cat. No. 1899

Sarafotoxin S6a Cys-Ser-Cys-Lys-Asp-Met-Thr-Asp-Lys-Glu-Cys-Leu-Asn-Phe-Cys-His-Gln-Asp-Val-Ile-Trp (Disulfide bridges: 1 - 15, 3 - 11)

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Biological Activity

Endothelin receptor agonist (EC50 values are 7.5 and > 150 nM for contraction of pig coronary artery and guinea pig aorta respectively). Nociceptive in vivo.

Technical Data

M.Wt:
2514.85
Formula:
C105H156N28O34S5
Sequence:
CSCKDMTDKECLNFCHQDVIW

(Modifications: Disulfide bridge between 1 - 15, 3 - 11)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
126738-34-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Raffa et al (1996) Endothelin-induced nociception in mice: mediation by ETA and ETB receptors. J.Pharmacol.Exp.Ther. 276 647. PMID: 8632332.

Schoeffter and Randriantsoa (1993) Differences between endothelial receptors mediating contraction of guinea-pig aorta and pig coronary artery. Eur.J.Pharmacol. 249 199. PMID: 8287901.

Minkes et al (1992) Comparison of responses to sarafotoxins 6a and 6c in pulmonary and systemic vascular beds. Am.J.Physiol. 262 H852. PMID: 1348398.

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Keywords: Sarafotoxin S6a, supplier, Endothelin, receptor, agonists, Non-Selective, ET, Receptors, SarafotoxinS6a, Tocris Bioscience, Non-selective Endothelin Agonist products

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