Calcineurin Autoinhibitory Peptide

Cat. No. 1891

Calcineurin autoinhibitory peptide Ile-Thr-Ser-Phe-Glu-Glu-Ala-Lys-Gly-Leu-Asp-Arg-Ile-Asn-Glu-Arg-Met-Pro-Pro-Arg-Arg-Asp-Ala-Met-Pro

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Alternative Name: Autoinhibitory peptide 457-482

Biological Activity

Selective inhibitor of Ca2+-calmodulin-dependent protein phosphatase (calcineurin) (IC50 ~ 10 μM). Does not inhibit PP1, PP2A or CaM kinase II (IC50 > 100 mM).

Technical Data

Soluble to 1 mg/ml in water
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Perrino et al (1995) Calcium regulation of calcineurin phosphatase activity by its B subunit and calmodulin. J.Biol.Chem. 270 340. PMID: 7814394.

Yokoyama and Wang (1994) The role of the autoinhibitory domain in differential metal ion activation of calmodulin-stimulated phosphatase. FEBS Lett. 337 128. PMID: 8287965.

Hashimoto et al (1990) Identification of an autoinhibitory domain in calcineurin. J.Biol.Chem. 265 1924. PMID: 2153670.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Calcineurin Autoinhibitory Peptide include:

Krenz et al (2015) Tonic 5nM DA stabilizes neuronal output by enabling bidirectional activity-dependent regulation of the hyperpolarization activated current via PKA and calcineurin. PLoS One 10 e0117965. PMID: 25692473.

Do you know of a great paper that uses Calcineurin Autoinhibitory Peptide from Tocris? If so please let us know.

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Keywords: Calcineurin autoinhibitory peptide, supplier, Selective, calcineurin, inhibitors, inhibits, Protein, Ser/Thr, Phosphatases, Autoinhibitory, peptide, 457-482, Tocris Bioscience, Protein Ser/Thr Phosphatases Inhibitor products

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