Cat. No. 1889

[Leu5]-Enkephalin Tyr-Gly-Gly-Phe-Leu

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Alternative Names: ICI 114740, Dynorphin-(1-5), YGGFL

Biological Activity

Endogenous opioid agonist peptide; inhibits electrically stimulated contractions in mouse vas deferens (IC50 = 11.4 nM). Short-acting in vivo.

Technical Data

Soluble to 1 mg/ml in water
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

DiMaio et al (1982) Synthesis and pharmacological characterization in vitro of cyclic enkephalin analogues: effect of conformational constraints on opiate receptor selectivity. J.Med.Chem. 25 1432. PMID: 6296388.

Law and Loh (1978) 3H-Leu5-enkephalin specific binding to synaptic membrane - comparison with 3H-dihydromorphine and 3H-naloxone. Res.Commun.Chem.Pathol.Pharmacol. 21 409. PMID: 705021.

Meunier et al (1977) Binding of Leu5-enkephalin and Met5-enkephalin to a particulate fraction from rat cerebrum. FEBS Lett. 77 209. PMID: 862920.

If you know of a relevant reference for [Leu5]-Enkephalin please let us know.

Citations are publications that use Tocris products. Selected citations for [Leu5]-Enkephalin include:

Markkanen and Petäjä-Repo (2008) N-glycan-mediated quality control in the endoplasmic reticulum is required for the expression of correctly folded delta-opioid receptors at the cell surface. J Biol Chem 283 29086. PMID: 18703511.

Do you know of a great paper that uses [Leu5]-Enkephalin from Tocris? If so please let us know.

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Keywords: [Leu5]-Enkephalin, supplier, Endogenous, opioids, agonists, peptide, Receptors, ICI114740, enkephalin, Tocris Bioscience, Miscellaneous Opioid Agonist products

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