[Leu5]-Enkephalin

Cat. No. 1889

[Leu5]-Enkephalin Tyr-Gly-Gly-Phe-Leu

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Alternative Names: ICI 114740, Dynorphin-(1-5), YGGFL

Biological Activity

Endogenous opioid agonist peptide; inhibits electrically stimulated contractions in mouse vas deferens (IC50 = 11.4 nM). Short-acting in vivo.

Technical Data

M.Wt:
555.63
Formula:
C28H37N5O7
Sequence:
YGGFL
Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
58822-25-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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DiMaio et al (1982) Synthesis and pharmacological characterization in vitro of cyclic enkephalin analogues: effect of conformational constraints on opiate receptor selectivity. J.Med.Chem. 25 1432. PMID: 6296388.

Law and Loh (1978) 3H-Leu5-enkephalin specific binding to synaptic membrane - comparison with 3H-dihydromorphine and 3H-naloxone. Res.Commun.Chem.Pathol.Pharmacol. 21 409. PMID: 705021.

Meunier et al (1977) Binding of Leu5-enkephalin and Met5-enkephalin to a particulate fraction from rat cerebrum. FEBS Lett. 77 209. PMID: 862920.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for [Leu5]-Enkephalin include:

Markkanen and Petäjä-Repo (2008) N-glycan-mediated quality control in the endoplasmic reticulum is required for the expression of correctly folded delta-opioid receptors at the cell surface. J Biol Chem 283 29086. PMID: 18703511.

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Keywords: [Leu5]-Enkephalin, supplier, Endogenous, opioids, agonists, peptide, Receptors, ICI114740, enkephalin, Tocris Bioscience, Miscellaneous Opioid Agonist products

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