MLCK inhibitor peptide 18

Cat. No. 1885

MLCK Inhibitor Peptide 18 Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys-NH2

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Alternative Name: Myosin Light Chain Kinase Inhibitor Peptide 18

Biological Activity

Selective competitive inhibitor of myosin light chain kinase (IC50 = 50 nM). Displays 4000-fold selectivity over CaM kinase II and does not inhibit PKA. Cell permeable.

Technical Data

M.Wt:
1324.64
Formula:
C60H105N23O11
Sequence:
RKKYKYRRK

(Modifications: Lys-9 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
224579-74-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Zolotarevsky et al (2002) A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease. Gastroenterology 123 163. PMID: 12105845.

Lukas et al (1999) Identification of novel classes of protein kinase inhibitors using combinatorial peptide chemistry based on functional genomics knowledge. J.Med.Chem. 42 910. PMID: 10072688.

If you know of a relevant reference for MLCK inhibitor peptide 18 please let us know.

Citations are publications that use Tocris products. Selected citations for MLCK inhibitor peptide 18 include:

Wang et al (2012) Inhibition of TNF-α improves the bladder dysfunction that is associated with type 2 diabetes. Proc Natl Acad Sci U S A 61 2134. PMID: 22688336.

Do you know of a great paper that uses MLCK inhibitor peptide 18 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: MLCK Inhibitor Peptide 18, supplier, Selective, inhibitors, inhibits, myosin, light, chain, kinases, MLCK, Inhibitor, Peptide18, Tocris Bioscience, Myosin Light Chain Kinase Inhibitor products

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