Cat. No. 1884
Alternative Name: GPAnt-2 analog
Biological ActivitySubstance P analog that inhibits activation of Gq/11 by M1 muscarinic ACh receptors. Does not inhibit Gi/o activation by M2 ACh receptors.
(Modifications: Trp-7, Trp-9, Trp-10 = D-Trp, Met-11 = C-terminal Amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Mukai et al (1992) G protein antagonists. A novel hydrophobic peptide competes with receptor for G protein binding. J.Biol.Chem. 267 16237. PMID: 1379592.
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Citations are publications that use Tocris products. Selected citations for [D-Trp7,9,10]-Substance P include:
Nordman and Kabbani (2014) Microtubule dynamics at the growth cone are mediated by α7 nicotinic receptor activation of a Gαq and IP3 receptor pathway. Diabetes 28 2995. PMID: 24687992.
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Keywords: [D-Trp 7,9,10]-Substance P, supplier, inhibitors, inhibits, M1, ACh, receptor, activation, Gq/11, G-Protein, Heterotrimeric, [D-Trp7910]-SubstanceP, Tocris Bioscience, G Protein (Heterotrimeric) Inhibitor products
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