[D-Trp7,9,10]-Substance P

Cat. No. 1884

[D-Trp 7,9,10]-Substance P Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-D-Trp-Met-NH2

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Alternative Name: GPAnt-2 analog

Biological Activity

Substance P analog that inhibits activation of Gq/11 by M1 muscarinic ACh receptors. Does not inhibit Gi/o activation by M2 ACh receptors.

Technical Data

M.Wt:
1588.89
Formula:
C79H105N21O13S
Sequence:
RPKPQQWFWWM

(Modifications: Trp-7, Trp-9, Trp-10 = D-Trp, Met-11 = C-terminal Amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Store at -20°C
CAS No:
89430-38-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Mukai et al (1992) G protein antagonists. A novel hydrophobic peptide competes with receptor for G protein binding. J.Biol.Chem. 267 16237. PMID: 1379592.

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Keywords: [D-Trp 7,9,10]-Substance P, supplier, inhibitors, inhibits, M1, ACh, receptor, activation, Gq/11, G-Protein, Heterotrimeric, [D-Trp7910]-SubstanceP, Tocris Bioscience, G Protein (Heterotrimeric) Inhibitor products

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