cGMP Dependent Kinase Inhibitor Peptide

Cat. No. 1883

cGMP dependent kinase inhibitor peptide Arg-Lys-Arg-Ala-Arg-Lys-Glu

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Alternative Name: [Ala32]H2B(29-35)

Biological Activity

Competitive inhibitor of cGMP-dependent protein kinase (PKG); analog of a substrate peptide corresponding to a phosphorylation site of histone H2B. Competes with synthetic substrates (Ki = 86 mM) but does not inhibit phosphorylation of intact histones by PKG. Inhibits phosphorylation of intact histones by PKA.

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Bhatnagar et al (1988) Synthetic peptide analogues differentially alter the binding affinities of cyclic nucleotide dependent protein kinases for nucleotide substrates. Biochemistry 27 1988. PMID: 2837278.

Glass et al (1986) Differential and common recognition of the catalytic sites of the cGMP-dependent and cAMP-dependent protein kinases by inhibitory peptides derived from the heat-stable inhibitor protein. J.Biol.Chem. 261 12166. PMID: 3017964.

Glass (1983) Differential responses of cyclic GMP-dependent and cyclic AMP-dependent protein kinases to synthetic peptide inhibitors. Biochem.J. 213 159. PMID: 6615418.

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Keywords: cGMP dependent kinase inhibitor peptide, supplier, inhibitors, inhibits, protein, kinases, A, G, PKA, PKG, Tocris Bioscience, Protein Kinase A Inhibitor products

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