U 46619

Cat. No. 1932

U 46619 C21H34O4 [56985-40-1]

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Alternative Name: 9,11-Dideoxy-9a,11a-methanoepoxy prostaglandin F2a

Chemical Name: (5Z)-7-[(1R,4S,5S,6R)-6-[(1E,3S)-3-Hydroxy-1-octenyl]-2-oxabicyclo[2.2.1]hept-5-yl]-5-heptenoic acid

Biological Activity

PGH2 (TXA2) analog that is a potent and stable thromboxane A2 (TP) receptor agonist (EC50 = 0.035 μM). Potently stimulates TP receptor-mediated, but not other prostaglandin receptor-mediated responses in various in vitro preparations. Activates ERK-1 and ERK-2 in HEK 293 cells expressing TPα and TPβ receptors.

Technical Data

M.Wt:
350.5
Formula:
C21H34O4
Solubility:
Soluble in methyl acetate (supplied pre-dissolved -10mg/ml)
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
56985-40-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Miggin and Kinsella (2002) Regulation of extracellular signal-regulated kinase cascades by α- and β-isoforms of the human thromboxane A2 receptor. Mol.Pharmacol. 61 817. PMID: 11901221.

Morinelli et al (1987) Receptor-mediated effects of a PGH2 analogue (U 46619) on human platelets. Am.J.Physiol. 253 H1035. PMID: 3688248.

Coleman et al (1981) Comparison of the actions of U-46619, a prostaglandin H2-analogue, with those of prostaglandin H2 and thromboxane A2 on some isolated smooth muscle preparations. Br.J.Pharmacol. 73 773. PMID: 7248665.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for U 46619 include:

Choi et al (2016) Inhibition of endoplasmic reticulum stress improves coronary artery function in the spontaneously hypertensive rats. Scientific Reports 6 31925. PMID: 27550383.

Lee and Diamond (2015) A human platelet calcium calculator trained by pairwise agonist scanning. PLoS One 11 e1004118. PMID: 25723389.

Pike et al (2014) Prenatal development is linked to bronchial reactivity: epidemiological and animal model evidence. Sci Rep 4 4705. PMID: 24740086.

Seto et al (2013) Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes. Diabetes 8 e66404. PMID: 23799098.

Chapman et al (2012) Platelets present antigen in the context of MHC class I. J Immunol 189 916. PMID: 22706078.

Lacar et al (2012) S phase entry of neural progenitor cells correlates with increased blood flow in the young subventricular zone. PLoS One 7 e31960. PMID: 22359646.

Do you know of a great paper that uses U 46619 from Tocris? If so please let us know.show all ▼show less ▲

View Related Products by Product Action

Keywords: U 46619, supplier, Potent, stable, thromboxane, A2, TP, receptor, agonists, TXA2, Prostanoid, prostaglandins, prostacyclins, eicosanoids, U46619, 9, 11-Dideoxy-9a, 11a-methanoepoxy, prostaglandinF2a, Tocris Bioscience, Prostanoid Receptor Agonist products

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