Cat. No. 1932
Alternative Name: 9,11-Dideoxy-9a,11a-methanoepoxy prostaglandin F2a
Chemical Name: (5Z)-7-[(1R,4S,5S,6R)-6-[(1E,3S)-3-
Biological ActivityPGH2 (TXA2) analog that is a potent and stable thromboxane A2 (TP) receptor agonist (EC50 = 0.035 μM). Potently stimulates TP receptor-mediated, but not other prostaglandin receptor-mediated responses in various in vitro preparations. Activates ERK-1 and ERK-2 in HEK 293 cells expressing TPα and TPβ receptors.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Miggin and Kinsella (2002) Regulation of extracellular signal-regulated kinase cascades by α- and β-isoforms of the human thromboxane A2 receptor. Mol.Pharmacol. 61 817. PMID: 11901221.
Morinelli et al (1987) Receptor-mediated effects of a PGH2 analogue (U 46619) on human platelets. Am.J.Physiol. 253 H1035. PMID: 3688248.
Coleman et al (1981) Comparison of the actions of U-46619, a prostaglandin H2-analogue, with those of prostaglandin H2 and thromboxane A2 on some isolated smooth muscle preparations. Br.J.Pharmacol. 73 773. PMID: 7248665.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for U 46619 include:
Choi et al (2016) Inhibition of endoplasmic reticulum stress improves coronary artery function in the spontaneously hypertensive rats. Scientific Reports 6 31925. PMID: 27550383.
Lee and Diamond (2015) A human platelet calcium calculator trained by pairwise agonist scanning. PLoS One 11 e1004118. PMID: 25723389.
Pike et al (2014) Prenatal development is linked to bronchial reactivity: epidemiological and animal model evidence. Sci Rep 4 4705. PMID: 24740086.
Seto et al (2013) Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes. Diabetes 8 e66404. PMID: 23799098.
Chapman et al (2012) Platelets present antigen in the context of MHC class I. J Immunol 189 916. PMID: 22706078.
Lacar et al (2012) S phase entry of neural progenitor cells correlates with increased blood flow in the young subventricular zone. PLoS One 7 e31960. PMID: 22359646.
View Related Products by Product Action
Keywords: U 46619, supplier, Potent, stable, thromboxane, A2, TP, receptor, agonists, TXA2, Prostanoid, prostaglandins, prostacyclins, eicosanoids, U46619, 9, 11-Dideoxy-9a, 11a-methanoepoxy, prostaglandinF2a, Tocris Bioscience, Prostanoid Receptor Agonist products
Find multiple products by catalog number
New Products in this Area
Selective GPR84 agonistIHR-Cy3
Potent fluorescent Smo antagonistRo 6842262
Potent LPA1 antagonistAMG 853
Potent dual CRTH2 and prostaglandin D2 (PGD2) receptor antagonistAM 4668
Potent FFA1 (GPR40) agonistCATPB
FFA2 antagonist/inverse agonistOleanolic acid
Selective GPBA receptor (TGR5) partial agonistPPTN hydrochloride
High affinity and selective P2Y14 antagonistItraconazole
SMO antagonist; acts at different binding site to cyclopamine (Cat No. 1623)SAR 216471 hydrochloride
Potent P2Y12 antagonist; orally available
April 10 - 13, 2017