BTS

Cat. No. 1870

BTS C14H15NO2S [1576-37-0]

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Chemical Name: 4-Methyl-N-(phenylmethyl)benzenesulfonamide

Biological Activity

Selective inhibitor of the ATPase activity of skeletal muscle myosin II subfragment 1 (S1) (IC50 ~ 5 mM). Reversibly blocks gliding motility and suppresses force and twitch production in fast skeletal muscle.

Technical Data

M.Wt:
261.34
Formula:
C14H15NO2S
Solubility:
Soluble to 70 mM in ethanol and to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
1576-37-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Ramachandran et al (2003) Skeletal muscle myosin cross-bridge cycling is necessary for myofibrillogenesis. Cell Motil.Cytoskeleton 55 61. PMID: 12673599.

Shaw et al (2003) Mechanism of inhibition of skeletal muscle actomyosin by N-benzyl-p-toluenesulfonamide. Biochemistry 42 6128. PMID: 12755615.

Cheung et al (2001) A small-molecule inhibitor of skeletal muscle myosin II. Nat.Cell.Biol. 4 83. PMID: 11744924.

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Citations are publications that use Tocris products. Selected citations for BTS include:

Lee et al (2015) Ca(2+) permeation and/or binding to CaV1.1 fine-tunes skeletal muscle Ca(2+) signaling to sustain muscle function. FASEB J 5 4. PMID: 25717360.

Magown et al (2015) Direct optical activation of skeletal muscle fibres efficiently controls muscle contraction and attenuates denervation atrophy. Nat Commun 6 8506. PMID: 26460719.

Thorne et al (2012) Firefly luciferase in chemical biology: a compendium of inhibitors, mechanistic evaluation of chemotypes, and suggested use as a reporter. Chem Biol 19 1060. PMID: 22921073.

Boncompagni et al (2010) The I4895T mutation in the type 1 ryanodine receptor induces fiber-type specific alterations in skeletal muscle that mimic premature aging. Aging Cell 9 958. PMID: 20961389.

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Keywords: BTS, supplier, Selective, inhibitors, inhibits, skeletal, muscle, myosin, II, ATPase, activity, Tocris Bioscience, Myosin Inhibitor products

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