Ipsapirone

Cat. No. 1869

Ipsapirone C19H23N5O3S [95847-70-4]

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Alternative Name: TVX Q 7821

Chemical Name: 2-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-1,2-benzisothiazol-3(2H)-one-1,1-dioxide

Biological Activity

Selective 5-HT1A receptor agonist (Ki = 10 nM). Anxiolytic in vivo.

Technical Data

M.Wt:
401.48
Formula:
C19H23N5O3S
Solubility:
Soluble to 10 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
95847-70-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Maj et al (1987) Central action of ipsapirone, a new anxiolytic drug, on serotoninergic, noradrenergic and dopaminergic functions. J.Neural.Transm. 70 1. PMID: 2889795.

Glaser and Traber (1985) Binding of the putative anxiolytic TVX Q 7821 to hippocampal 5-hydroxytryptamine (5-HT) recognition sites. Naunyn-Schmied.Arch.Pharmacol. 329 211.

Traber et al (1984) Brain serotonin receptors as a target for the putative anxiolytic TVX Q 7821. Brain Res.Bull. 12 741. PMID: 6541079.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Ipsapirone include:

Rozeske et al (2011) Uncontrollable, but not controllable, stress desensitizes 5-HT1A receptors in the dorsal raphe nucleus. J Neurosci 31 14107. PMID: 21976495.

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Keywords: Ipsapirone, supplier, Selective, 5-HT1A, agonists, Serotonin, Receptors, TVXQ7821, Tocris Bioscience, 5-HT1A Receptor Agonist products

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