Cat. No. 1869
Alternative Name: TVX Q 7821
Chemical Name: 2-[4-[4-(2-Pyrimidinyl)-1-piperazin
Biological ActivitySelective 5-HT1A receptor agonist (Ki = 10 nM). Anxiolytic in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Maj et al (1987) Central action of ipsapirone, a new anxiolytic drug, on serotoninergic, noradrenergic and dopaminergic functions. J.Neural.Transm. 70 1. PMID: 2889795.
Glaser and Traber (1985) Binding of the putative anxiolytic TVX Q 7821 to hippocampal 5-hydroxytryptamine (5-HT) recognition sites. Naunyn-Schmied.Arch.Pharmacol. 329 211.
Traber et al (1984) Brain serotonin receptors as a target for the putative anxiolytic TVX Q 7821. Brain Res.Bull. 12 741. PMID: 6541079.
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Citations are publications that use Tocris products. Selected citations for Ipsapirone include:
Rozeske et al (2011) Uncontrollable, but not controllable, stress desensitizes 5-HT1A receptors in the dorsal raphe nucleus. J Neurosci 31 14107. PMID: 21976495.
Do you know of a great paper that uses Ipsapirone from Tocris? If so please let us know.
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Keywords: Ipsapirone, supplier, Selective, 5-HT1A, agonists, Serotonin, Receptors, TVXQ7821, Tocris Bioscience, 5-HT1A Receptor Agonist products
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