U0124

Cat. No. 1868

U0124 C8H10N4S2 [108923-79-1]

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Chemical Name: Bis[amino(methylthio)methylene]butanedinitrile

Biological Activity

Inactive analog of U0126 (Cat. No. 1144). Used as a negative control. Does not inhibit MEK at concentrations up to 100 μM.

Technical Data

M.Wt:
226.31
Formula:
C8H10N4S2
Solubility:
Soluble to 100 mM in DMSO
Storage:
Store at RT
CAS No:
108923-79-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Sekar et al (2001) Concerted transcriptional activation of the low density lipoprotein receptor gene by insulin and luteinizing hormone in cultured porcine granulosa-luteal cells: possible convergence of protein kinase A, phosphatidylinositol 3-kinase, and mitogen-activated protein kinase signaling pathways. Endocrinology 142 2921. PMID: 11416012.

Fitzgerald (2000) Regulation of voltage-dependent calcium channels in rat sensory neurones involves a Ras-mitogen-activated protein kinase pathway. J.Physiol. 527 433. PMID: 10990531.

Favata et al (1998) Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J.Biol.Chem. 273 18623. PMID: 9660836.

If you know of a relevant reference for U0124 please let us know.

Citations are publications that use Tocris products. Selected citations for U0124 include:

Melemedjian et al (2013) mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK. Pain 154 1080. PMID: 23607966.

Philips et al (2013) MAPK establishes a molecular context that defines effective training patterns for long-term memory formation. Nutr Metab Cardiovasc Dis 33 7565. PMID: 23616561.

Bentley et al (2011) Influence of chylomicron remnants on human monocyte activation in vitro. Skelet Muscle 21 871. PMID: 20674313.

Melemedjian et al (2011) Targeting adenosine monophosphate-activated protein kinase (AMPK) in preclinical models reveals a potential mechanism for the treatment of neuropathic pain. Mol Pain 7 70. PMID: 21936900.

Kolber et al (2010) Activation of metabotropic glutamate receptor 5 in the amygdala modulates pain-like behavior. J Neurosci 30 8203. PMID: 20554871.

Do you know of a great paper that uses U0124 from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: U0124, supplier, Mitogen-Activated, Protein, Kinase, kinases, MEK, Tocris Bioscience, MEK Inhibitor products

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