Cat. No. 1868
Chemical Name: Bis[amino(methylthio)methylene]buta
Biological ActivityInactive analog of U0126 (Cat. No. 1144). Used as a negative control. Does not inhibit MEK at concentrations up to 100 μM.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Sekar et al (2001) Concerted transcriptional activation of the low density lipoprotein receptor gene by insulin and luteinizing hormone in cultured porcine granulosa-luteal cells: possible convergence of protein kinase A, phosphatidylinositol 3-kinase, and mitogen-activated protein kinase signaling pathways. Endocrinology 142 2921. PMID: 11416012.
Fitzgerald (2000) Regulation of voltage-dependent calcium channels in rat sensory neurones involves a Ras-mitogen-activated protein kinase pathway. J.Physiol. 527 433. PMID: 10990531.
Favata et al (1998) Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J.Biol.Chem. 273 18623. PMID: 9660836.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for U0124 include:
Melemedjian et al (2013) mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK. Pain 154 1080. PMID: 23607966.
Melemedjian et al (2011) Targeting adenosine monophosphate-activated protein kinase (AMPK) in preclinical models reveals a potential mechanism for the treatment of neuropathic pain. Mol Pain 7 70. PMID: 21936900.
Do you know of a great paper that uses U0124 from Tocris? If so please let us know.
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Keywords: U0124, supplier, Mitogen-Activated, Protein, Kinase, kinases, MEK, Tocris Bioscience, MEK Inhibitor products
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