U0124

Cat. No. 1868

U0124 C8H10N4S2 [108923-79-1]

Price and Availability

For U0124 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: Bis[amino(methylthio)methylene]butanedinitrile

Biological Activity

Inactive analog of U0126 (Cat. No. 1144). Used as a negative control. Does not inhibit MEK at concentrations up to 100 μM.

Technical Data

M.Wt:
226.31
Formula:
C8H10N4S2
Solubility:
Soluble to 100 mM in DMSO
Storage:
Store at RT
CAS No:
108923-79-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Sekar et al (2001) Concerted transcriptional activation of the low density lipoprotein receptor gene by insulin and luteinizing hormone in cultured porcine granulosa-luteal cells: possible convergence of protein kinase A, phosphatidylinositol 3-kinase, and mitogen-activated protein kinase signaling pathways. Endocrinology 142 2921. PMID: 11416012.

Fitzgerald (2000) Regulation of voltage-dependent calcium channels in rat sensory neurones involves a Ras-mitogen-activated protein kinase pathway. J.Physiol. 527 433. PMID: 10990531.

Favata et al (1998) Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J.Biol.Chem. 273 18623. PMID: 9660836.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for U0124 include:

Melemedjian et al (2013) mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK. Pain 154 1080. PMID: 23607966.

Philips et al (2013) MAPK establishes a molecular context that defines effective training patterns for long-term memory formation. Nutr Metab Cardiovasc Dis 33 7565. PMID: 23616561.

Bentley et al (2011) Influence of chylomicron remnants on human monocyte activation in vitro. Skelet Muscle 21 871. PMID: 20674313.

Melemedjian et al (2011) Targeting adenosine monophosphate-activated protein kinase (AMPK) in preclinical models reveals a potential mechanism for the treatment of neuropathic pain. Mol Pain 7 70. PMID: 21936900.

Kolber et al (2010) Activation of metabotropic glutamate receptor 5 in the amygdala modulates pain-like behavior. J Neurosci 30 8203. PMID: 20554871.

Do you know of a great paper that uses U0124 from Tocris? If so please let us know.show all ▼show less ▲

View Related Products by Target

MEK

View Related Products by Product Action

Keywords: U0124, supplier, Mitogen-Activated, Protein, Kinase, kinases, MEK, Tocris Bioscience, MEK Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Kinase Inhibitor Toolbox

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

divider line

Kinases Product Listing

Kinases Product Listing

Our Kinase listing highlights over 400 products for kinase research. Request copy or view PDF today.

divider line

Pain Research Product Guide

Pain Research Product Guide

Our Pain guide highlights over 280 products for Pain research. Request copy or view PDF today.

divider line

MAPK Signaling Review

Written by E. Zaganjor & M. Cobb

MAPK Signaling Scientific Review

Our MAPK signaling review gives an overview of the MAPK signaling cascade and summarizes small molecule inhibitors of the pathway. Request copy or view PDF today.

divider line

VEGF Pathway & Anti-Angiogenic Therapy

Written by N. Ferrara & Y. Crawford

Angiogenesis Life Science Poster

A summary of antiangiogenic therapies targeting the VEGF pathway and the mechanisms of therapy resistance. Request copy today.

divider line

MAPK Pathway

MAPK Signaling Pathway

The MAPK family kinases respond to extracellular stimuli such as heat and stress to mediate intracellular signals. View pathway or download PDF today.

divider line

New Products in this Area

RMM 46

MSK/RSK family kinase inhibitor

LTURM 34

Potent DNA-PK inhibitor

MLi-2

Potent and selective LRRK2 inhibitor

LTURM 36

PI 3-kinase δ inhibitor

PI 3065

Potent and selective PI 3-kinase p110δ inhibitor

AZ PFKFB3 67

Potent and selective PFKFB3 inhibitor

STOCK2S 26016

Lysine deficient protein kinase (WNK) signaling inhibitor

rac-CCT 250863

Potent Nek2 inhibitor

Roscovitine

Potent, selective cyclin-dependent kinase inhibitor

Enzastaurin

Potent PKCβ inhibitor

BMS 265246

Potent cdk1/2 inhibitor

Autocamtide-2-related inhibitory peptide, myristoylated

CaM kinase II inhibitor; enhanced cell permeable derivative of Autocamtide-2-related inhibitory peptide

MP A08

Selective ATP competitive SphK1 and 2 inhibitor; cell permeable

Akti-1/2

Potent and selective dual Akt1 and 2 inhibitor

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.