Cat. No. 1867
Chemical Name: 6-Chloro-7-[[2-(4-morpholinyl)ethyl
Biological ActivityPotent, selective inhibitor of Cdc25 dual specificity phosphatases (Ki values are 29, 95 and 89 nM for human Cdc25A, Cdc25B2 and Cdc25C respectively); > 20- and > 450-fold selective over VHR and PTP1B phosphatases respectively. Arrests cells at both G1 and G2/M phase and blocks cdk2 and cdk1 activation. Blocks proliferation of a range of human tumor cell lines (IC50 = 0.2 - 35 μM).
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Brisson et al (2005) Redox regulation of cdc25B by cell-active Quinolinediones. Mol.Pharmacol. 68 1810. PMID: 16155209.
Pu et al (2002) Dual G1 and G2 phase inhibition by a novel, selective Cdc25 inhibitor 7-chloro-6-(2-morpholin-4-ylethylamino)-quinoline-5,8-dione. J.Biol.Chem. 277 46877. PMID: 12356752.
Lazo et al (2001) Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25. J.Med.Chem. 44 4042. PMID: 11708908.
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Keywords: NSC 663284, supplier, Potent, selective, Cdc25, phosphatase, inhibitors, inhibits, Cyclin-Dependent, Protein, Kinase, Cdk, Kinases, Dual-Specificity, Phosphatases, NSC663284, Tocris Bioscience, Cdc25 Phosphatase Inhibitor products