NSC 663284

Cat. No. 1867

NSC 663284 C15H16ClN3O3 [383907-43-5]

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Chemical Name: 6-Chloro-7-[[2-(4-morpholinyl)ethyl]amino]-5,8-quinolinedione

Biological Activity

Potent, selective inhibitor of Cdc25 dual specificity phosphatases (Ki values are 29, 95 and 89 nM for human Cdc25A, Cdc25B2 and Cdc25C respectively); > 20- and > 450-fold selective over VHR and PTP1B phosphatases respectively. Arrests cells at both G1 and G2/M phase and blocks cdk2 and cdk1 activation. Blocks proliferation of a range of human tumor cell lines (IC50 = 0.2 - 35 μM).

Technical Data

Soluble to 50 mM in DMSO and to 50 mM in ethanol
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Brisson et al (2005) Redox regulation of cdc25B by cell-active Quinolinediones. Mol.Pharmacol. 68 1810. PMID: 16155209.

Pu et al (2002) Dual G1 and G2 phase inhibition by a novel, selective Cdc25 inhibitor 7-chloro-6-(2-morpholin-4-ylethylamino)-quinoline-5,8-dione. J.Biol.Chem. 277 46877. PMID: 12356752.

Lazo et al (2001) Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25. J.Med.Chem. 44 4042. PMID: 11708908.

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Keywords: NSC 663284, supplier, Potent, selective, Cdc25, phosphatase, inhibitors, inhibits, Cyclin-Dependent, Protein, Kinase, Cdk, Kinases, Dual-Specificity, Phosphatases, NSC663284, Tocris Bioscience, Cdc25 Phosphatase Inhibitor products

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