MRS 1845

Cat. No. 1866

MRS 1845 C21H22N2O6 [544478-19-5]

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Alternative Name: N-Propylargylnitrendipine

Chemical Name: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-1-(2-propynyl)-3,5-pyridinedicarboxylic acid ethyl, methyl ester

Biological Activity

Potent blocker of store-operated Ca2+ channels; inhibits capacitative Ca2+ influx in HL-60 cells (IC50 = 1.7 mM).

Technical Data

M.Wt:
398.41
Formula:
C21H22N2O6
Solubility:
Soluble to 10 mM in ethanol with gentle warming and to 10 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
544478-19-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Szikra et al (2009) Calcium homeostasis and cone signaling are regulated by interactions between calcium stores and plasma membrane ion channels. PLoS ONE 4 e6723. PMID: 19696927.

Szikra et al (2008) Depletion of calcium stores regulates calcium influx and signal transmission in rod photoreceptors. J.Physiol. 586 4859. PMID: 18755743.

Harper et al (2003) Dihydropyridines as inhibitors of capacitative calcium entry in leukemic HL-60 cells. Biochem.Pharmacol. 65 329. PMID: 12527326.

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Citations are publications that use Tocris products. Selected citations for MRS 1845 include:

Berlinguer-Palmini et al (2013) GPR35 activation reduces Ca2+ transients and contributes to the kynurenic acid-dependent reduction of synaptic activity at CA3-CA1 synapses. PLoS One 8 e82180. PMID: 24312407.

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Keywords: MRS 1845, supplier, Potent, SOC, inhibitors, inhibits, blocks, capacitative, Ca2+, entry, Calcium, Signaling, Signalling, Agents, General, Channels, Store-Operated, MRS1845, Tocris Bioscience, Other Calcium Channel Blocker products

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