Cat. No. 1866
Alternative Name: N-Propylargylnitrendipine
Chemical Name: 1,4-Dihydro-2,6-dimethyl-4-(3-nitro
Biological ActivityPotent blocker of store-operated Ca2+ channels; inhibits capacitative Ca2+ influx in HL-60 cells (IC50 = 1.7 mM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Szikra et al (2009) Calcium homeostasis and cone signaling are regulated by interactions between calcium stores and plasma membrane ion channels. PLoS ONE 4 e6723. PMID: 19696927.
Szikra et al (2008) Depletion of calcium stores regulates calcium influx and signal transmission in rod photoreceptors. J.Physiol. 586 4859. PMID: 18755743.
Harper et al (2003) Dihydropyridines as inhibitors of capacitative calcium entry in leukemic HL-60 cells. Biochem.Pharmacol. 65 329. PMID: 12527326.
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Citations are publications that use Tocris products. Selected citations for MRS 1845 include:
Berlinguer-Palmini et al (2013) GPR35 activation reduces Ca2+ transients and contributes to the kynurenic acid-dependent reduction of synaptic activity at CA3-CA1 synapses. PLoS One 8 e82180. PMID: 24312407.
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Keywords: MRS 1845, supplier, Potent, SOC, inhibitors, inhibits, blocks, capacitative, Ca2+, entry, Calcium, Signaling, Signalling, Agents, General, Channels, Store-Operated, MRS1845, Tocris Bioscience, Other Calcium Channel Blocker products