Cat. No. 1862
Chemical Name: 2,2-Bis(hydroxymethyl)-1-azabicyclo
Biological ActivitySelectively restores mutant p53 activity in tumor cells via activation of Bax and PUMA. Induces apoptosis and inhibits growth of tumors with mutant p53.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Wang et al (2007) PRIMA-1 induces apoptosis by inhibiting JNK signalling but promoting the activation of Bax. Biochem.Biophys.Res.Commun. 352 203. PMID: 17113036.
Bykov et al (2002) Restoration of the tumour suppressor function to mutant p53 by a low-molecular-weight compound. Nat.Med. 8 282. PMID: 11875500.
Bykov et al (2002) Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known anticancer drugs: a statistical analysis of information in the National Cancer Institute database. Carcinogenesis 23 2011. PMID: 12507923.
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Citations are publications that use Tocris products. Selected citations for PRIMA-1 include:
Grinter et al (2011) An inverse docking approach for identifying new potential anti-cancer targets. J Neurosci 29 795. PMID: 21315634.
Benakanakere et al (2009) Regression of progestin-accelerated 7,12-dimethylbenz[a]anthracene-induced mammary tumors in Sprague-Dawley rats by p53 reactivation and induction of massive apoptosis: a pilot study. Endocr Relat Cancer 16 85. PMID: 19075036.
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Keywords: PRIMA-1, supplier, Restores, mutant, p53, activity, induces, apoptosis, Transcription, Factors, Bax, PUMA, Tocris Bioscience, p53 products