PD 144418 oxalate
Cat. No. 2606
Chemical Name: 1,2,3,6-Tetrahydro-5-[3-(4-methylph
Biological ActivityHigh affinity, selective σ1 ligand (Ki values are 0.08 and 1377 nM for σ1 and σ2 respectively). Displays no significant activity at a wide range of other receptors, ion channels and enzymes. Antagonizes mescaline-induced scratching in mice following i.p. administration. Also attenuates cocaine-induced hyperactivity in mice.
Licensing InformationSold for research purposes under agreement from Pfizer Inc.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Lever et al (2014) Relationship between cerebral sigma-1 receptor occupancy and attenuation of cocaine's motor stimulatory effects in mice by PD144418. J.Pharmacol.Exp.Ther. 351 153. PMID: 25100754.
Akunne et al (1997) The pharmacology of the novel and selective sigma ligand, PD 144418. Neuropharmacology 36 51. PMID: 9144641.
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Citations are publications that use Tocris products. Selected citations for PD 144418 oxalate include:
Navarro et al (2015) Orexin-corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine. Autophagy 35 6639. PMID: 25926444.
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