PD 144418 oxalate

Cat. No. 2606

PD 144418 oxalate C18H22N2O.C2H2O4 [154130-99-1]

Price and Availability

For PD 144418 oxalate pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 1,2,3,6-Tetrahydro-5-[3-(4-methylphenyl)-5-isoxazolyl]-1-propylpyridine oxalate

Biological Activity

High affinity, selective σ1 ligand (Ki values are 0.08 and 1377 nM for σ1 and σ2 respectively). Displays no significant activity at a wide range of other receptors, ion channels and enzymes. Antagonizes mescaline-induced scratching in mice following i.p. administration. Also attenuates cocaine-induced hyperactivity in mice.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M.Wt:
372.42
Formula:
C18H22N2O.C2H2O4
Solubility:
Soluble to 50 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
154130-99-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Lever et al (2014) Relationship between cerebral sigma-1 receptor occupancy and attenuation of cocaine's motor stimulatory effects in mice by PD144418. J.Pharmacol.Exp.Ther. 351 153. PMID: 25100754.

Akunne et al (1997) The pharmacology of the novel and selective sigma ligand, PD 144418. Neuropharmacology 36 51. PMID: 9144641.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for PD 144418 oxalate include:

Navarro et al (2015) Orexin-corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine. Autophagy 35 6639. PMID: 25926444.

Do you know of a great paper that uses PD 144418 oxalate from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: PD 144418 oxalate, supplier, High, affinity, selective, σ1, sigma1, ligands, Receptors, PD144418, oxalate, Pfizer, Tocris Bioscience, σ1 Receptor Ligand products

Quick Order

Find multiple products by catalog number

divider line

New Product Guide

New Product Guide (Fall/Winter 2016)

Our New Product guide highlights over 100 new products added in the second half of 2016. Request copy or view PDF today.

divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.