Cat. No. 1856
Chemical Name: [4-[3-(4-Acetyl-3-hydroxy-2-propylp
Biological ActivityPotent PPARδ agonist (Ki = 6 nM); displays > 100-fold selectivity for both mouse and human PPARδ receptors over other subtypes. Raises plasma cholesterol levels in vivo, in insulin-resistant db/db mice. Neuroprotective in models of cerebral infarction and Parkinson's disease.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Iwashita et al (2007) Neuroprotective efficacy of the peroxisome proliferator-activated receptor δ-selective agonists in vitro and in vivo. J.Pharmacol.Exp.Ther. 320 1087. PMID: 17167170.
Leibowitz et al (2000) Activation of PPARδ alters lipid metabolism in db/db mice. FEBS Lett. 473 333. PMID: 10818235.
Berger et al (1999) Novel peroxisome proliferator-activated receptor (PPAR)γ and PPARδ ligands produce distinct biological effects. J.Biol.Chem. 274 6718. PMID: 10037770.
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Keywords: L-165,041, supplier, Potent, PPARδ, PPARdelta, agonists, Peroxisome, Proliferator-Activating, Receptors, agonist, L165041, Tocris Bioscience, PPARδ Agonist products
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