Ro 60-0175 fumarate

Cat. No. 1854

Ro 60-0175 C11H12ClFN2.C4H4O4 [169675-09-6]

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Chemical Name: (αS)-6-Chloro-5-fluoro-α-methyl-1H-indole-1-ethanamine fumarate

Biological Activity

Potent, selective 5-HT2 receptor agonist; shows selectivity for the 5-HT2C subtype (pKi values are 9, 7.5, 5.4, 5.2 and 5.6 for human 5-HT2C, 2A, 1A, 6 and 7 receptors respectively). Centrally active following oral or systemic administration in vivo.

Technical Data

M.Wt:
342.75
Formula:
C11H12ClFN2.C4H4O4
Solubility:
Soluble to 5 mM in water and to 20 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
169675-09-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Jensen et al (2013) Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive properties. J.Med.Chem. 56 1211. PMID: 23301527.

Damjanoska et al (2003) Neuroendocrine evidence that (S)-2-(chloro-5-fluoro-indol-l-yl)-1-methylethylamine fumarate (Ro 60-0175) is not a selective 5-hydroxytryptamine2C receptor agonist. J.Pharmacol.Exp.Ther. 304 1209. PMID: 12604698.

Kennett et al (2000) Effects of Ro 60 0175, a 5-HT2C receptor agonist, in three animal models of anxiety. Eur.J.Pharmacol. 387 197. PMID: 10650160.

Martin et al (1998) 5-HT2C receptor agonists: pharmacological characteristics and therapeutic potential. J.Pharmacol.Exp.Ther. 286 913. PMID: 9694950.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Ro 60-0175 fumarate include:

Kasper et al (2015) Serotonin-2C receptor agonists decrease potassium-stimulated GABA release in the nucleus accumbens. J Neurophysiol 69 78. PMID: 25382408.

Martin et al (2015) 5-HT2C receptor desensitization moderates anxiety in 5-HTT deficient mice: from behavioral to cellular evidence. Synapse 18. PMID: 25522398.

Martin et al (2014) Effect of genetic and pharmacological blockade of GABA receptors on the 5-HT2C receptor function during stress. J Neurochem 131 566. PMID: 25113583.

Craige and Unterwald (2013) Serotonin (2C) receptor regulation of cocaine-induced conditioned place preference and locomotor sensitization. Behav Brain Res 238 206. PMID: 23103406.

Manvich et al (2012) Effects of serotonin 2C receptor agonists on the behavioral and neurochemical effects of cocaine in squirrel monkeys. J Pharmacol Exp Ther 341 424. PMID: 22328576.

Yu and Yamaguchi (2010) Endogenous serotonin acts on 5-HT2C-like receptors in key vocal areas of the brain stem to initiate vocalizations in Xenopus laevis. J Biol Chem 103 648. PMID: 19955293.

Yu and Yamaguchi (2009) 5-HT2C-like receptors in the brain of Xenopus laevis initiate sex-typical fictive vocalizations. J Neurophysiol 102 752. PMID: 19474172.

Do you know of a great paper that uses Ro 60-0175 fumarate from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Ro 60-0175, supplier, Potent, selective, 5-HT2C, agonists, Serotonin, Receptors, Ro60-0175, Tocris Bioscience, 5-HT2C Receptor Agonist products

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