Cat. No. 1852
Chemical Name: (3aS)-(-)-1,2,3,3a-Tetrahydro-3a-hy
Biological ActivitySelective inhibitor of myosin II ATPase activity (IC50 ~0.5 - 5 μM); active enantiomer of (±)-blebbistatin (Cat. No. 1760). Inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Limouze et al (2004) Specificity of blebbistatin, an inhibitor of myosin II. J.Muscle Res.Cell Motil. 25 337. PMID: 15548862.
Straight et al (2003) Dissecting temporal and spatial control of cytokinesis with a myosin II inhibitor. Science 299 1743. PMID: 12637748.
Straight et al (2002) Dissecting cytokinesis with small molecules. Amer.Soc.Cell Biol.Abstr. 2515.
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Keywords: (S)-(-)-Blebbistatin, supplier, Selective, inhibitors, inhibits, myosin, II, ATPase, Tocris Bioscience, Myosin Inhibitor products