Cat. No. 1852
Chemical Name: (3aS)-(-)-1,2,3,3a-Tetrahydro-3a-hy
Biological ActivitySelective inhibitor of myosin II ATPase activity (IC50 ~0.5 - 5 μM); active enantiomer of (±)-blebbistatin (Cat. No. 1760). Inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Limouze et al (2004) Specificity of blebbistatin, an inhibitor of myosin II. J.Muscle Res.Cell Motil. 25 337. PMID: 15548862.
Straight et al (2003) Dissecting temporal and spatial control of cytokinesis with a myosin II inhibitor. Science 299 1743. PMID: 12637748.
Straight et al (2002) Dissecting cytokinesis with small molecules. Amer.Soc.Cell Biol.Abstr. 2515.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses (S)-(-)-Blebbistatin from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: (S)-(-)-Blebbistatin, supplier, Selective, inhibitors, inhibits, myosin, II, ATPase, Tocris Bioscience, Myosin Inhibitor products
Find multiple products by catalog number
New Products in this Area
SERCA2 allosteric activator
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.