[Nle4,D-Phe7]-α-MSH

Cat. No. 3013

[Nle4,D-phe7]-a-MSH Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2

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Alternative Names: Melanotan I, MT-I, NDP-α-MSH

Biological Activity

Synthetic analog of α-MSH that is an agonist at melanocortin receptors (Ki values are 0.085, 0.4, 3.8 and 5.1 nM for MC1, MC3, MC4 and MC5 receptors respectively).

Technical Data

M.Wt:
1646.86
Formula:
C78H111N21O19
Sequence:
SYSXEHFRWGKPV

(Modifications: Ser-1 = N-terminal Ac, X = Nle, Phe-7 = D-Phe, Val-13 = C-terminal amide)

Solubility:
Soluble to 0.60 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
75921-69-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Wikber (1999) Melanocortin receptors: perspectives for novel drugs. Eur.J.Pharmacol. 375 295. PMID: 10443584.

Sawyer et al (1980) 4-Norleucine, 7-D-phenylalanine-α-melanocyte-stimulating hormone: a highly potent α-melanotropin with ultrapotent biological activity. Proc.Natl.Acad.Sci.USA 77 5754.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for [Nle4,D-Phe7]-α-MSH include:

Schellekens et al (2013) Promiscuous dimerization of the growth hormone secretagogue receptor (GHS-R1a) attenuates ghrelin-mediated signaling. J Biol Chem 288 181. PMID: 23161547.

Do you know of a great paper that uses [Nle4,D-Phe7]-α-MSH from Tocris? If so please let us know.

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Keywords: [Nle4,D-phe7]-a-MSH, supplier, Melanocortin, receptor, agonists, MC, Receptors, [Nle4, D-phe7]-α-MSH, alpha-MSH, MelanotanI, Tocris Bioscience, Melanocortin (MC) Receptor Agonist products

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