Exo1

Cat. No. 1850

Exo1 C15H12FNO3 [461681-88-9]

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Chemical Name: 2-[(4-Fluorobenzoyl)amino]-benzoic acid methyl ester

Biological Activity

Reversible inhibitor of vesicular trafficking between endoplasmic reticulum and Golgi apparatus. Modifies Golgi ADP-ribosylation factor (ARF)1 GTPase activity and inhibits exocytosis (IC50 ~ 20 mM). Has similar, but not identical, action to brefeldin A (Cat. No. 1231).

Technical Data

M.Wt:
273.26
Formula:
C15H12FNO3
Solubility:
Soluble to 25 mM in ethanol with gentle warming and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
461681-88-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Feng et al (2003) Exo1: A new chemical inhibitor of the exocytic pathway. Proc.Natl.Acad.Sci.U.S.A. 100 6469. PMID: 12738886.

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Citations are publications that use Tocris products.

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View Related Products by Product Action

Keywords: Exo1, supplier, inhibitors, inhibits, Golgi-ER, traffic, blocks, exocytosis, Golgi, ADP-ribosylation, factor, ARF1, GTPase, Tocris Bioscience, Translocation, Exocytosis & Endocytosis products

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