Cat. No. 1849
Chemical Name: 2-Butyl-3,4-dihydro-N,N-dimethyl-4-
Biological ActivityHighly potent and very selective non-peptide angiotensin AT1 receptor antagonist (IC50 values are 0.7 and > 10000 nM for AT1 and AT2 receptors respectively). Potently inhibits angiotensin II-induced contractions in isolated rabbit aorta (IC50 = 0.2 nM) and reduces blood pressure in hypertensive rats.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Mederski et al (1995) 4,5-Dihydro-4-oxo-3H-imidazo[4,5-c]pyridines: potent arylacetic acid-derived AT1 antagonists with improved affinity for the AT2 receptor. Bioorg.Med.Chem.Lett. 5 2665.
Mederski et al (1994) Non-peptide angiotensin II receptor antagonists: synthesis and biological activity of a series of novel 4,5-dihydro-4-oxo-3H-imidazo[4,5-c]pyridine derivatives. J.Med.Chem. 37 1632. PMID: 8201597.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses EMD 66684 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: EMD 66684, supplier, Potent, selective, non-peptide, AT1, antagonists, Receptors, Angiotensin, EMD66684, Tocris Bioscience, Angiotensin AT1 Receptor Antagonist products
Find multiple products by catalog number
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.