Cat. No. 1849
Chemical Name: 2-Butyl-3,4-dihydro-N,N-dimethyl-4-
Biological ActivityHighly potent and very selective non-peptide angiotensin AT1 receptor antagonist (IC50 values are 0.7 and > 10000 nM for AT1 and AT2 receptors respectively). Potently inhibits angiotensin II-induced contractions in isolated rabbit aorta (IC50 = 0.2 nM) and reduces blood pressure in hypertensive rats.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Mederski et al (1995) 4,5-Dihydro-4-oxo-3H-imidazo[4,5-c]pyridines: potent arylacetic acid-derived AT1 antagonists with improved affinity for the AT2 receptor. Bioorg.Med.Chem.Lett. 5 2665.
Mederski et al (1994) Non-peptide angiotensin II receptor antagonists: synthesis and biological activity of a series of novel 4,5-dihydro-4-oxo-3H-imidazo[4,5-c]pyridine derivatives. J.Med.Chem. 37 1632. PMID: 8201597.
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Keywords: EMD 66684, supplier, Potent, selective, non-peptide, AT1, antagonists, Receptors, Angiotensin, EMD66684, Tocris Bioscience, Angiotensin AT1 Receptor Antagonist products