Cat. No. 1846
Biological ActivityAnnexin/lipocortin 1-mimetic peptide; inhibits leukocyte extravasation. Reduces neutrophil adhesion and emigration, and promotes detachment of neutrophils from activated mesenteric endothelium in mice in vivo.
Licensing InformationSold under license from The William Harvey Research Institute
(Modifications: Ala-1 = N-terminal Ac)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Perretti et al (2001) Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics. Am.J.Pathol. 158 1969. PMID: 11395373.
Lim et al (1998) Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1 Proc.Natl.Acad.Sci.U.S.A. 95 14535. PMID: 9826735.
If you know of a relevant reference for Ac2-12 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Ac2-12 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: Ac2-12, supplier, Annexin, lipocortin, 1-mimetic, inhibits, inhibitors, leukocyte, extravasation, Adhesion, Molecules, Tocris Bioscience, Cell Adhesion Molecule products
Find multiple products by catalog number
April 22 - 26, 2017
Chicago, IL, USA