Ac2-26

Cat. No. 1845

Ac2-26 Ac-Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-Gln-Ala-Trp-Phe-Ile-Glu-Asn-Glu-Glu-Gln-Glu-Tyr-Val-Gln-Thr-Val-Lys

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Biological Activity

Annexin/lipocortin 1-mimetic peptide; inhibits leukocyte extravasation. Reduces neutrophil adhesion and emigration, promotes detachment of neutrophils from activated mesenteric endothelium and accelerates epithelial wound repair after induced colonic injury in mice in vivo. Anti-inflammatory.

Licensing Information

Sold under license from The William Harvey Research Institute

Technical Data

M.Wt:
3089.46
Formula:
C141H210N32O44S
Sequence:
AMVSEFLKQAWFIENEEQEYVQTVK

(Modifications: Ala-1 = N-terminal Ac)

Solubility:
Soluble to 1 mg/ml in PBS
Storage:
Desiccate at -20°C
CAS No:
151988-33-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Leoni et al (2015) Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. J.Clin.Invest. 125 1215. PMID: 25664854.

Perretti and Gavins (2003) Annexin 1: an endogenous anti-inflammatory protein. News Physiol.Sci. 18 60. PMID: 12644621.

Lim et al (1998) Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1. Proc.Natl.Acad.Sci.U.S.A. 95 14535. PMID: 9826735.

Perretti et al (1993) Lipocortin-1 fragments inhibit neutrophil accumulation and neutrophil-dependent edema in the mouse. A qualitative comparison with an anti-CD11b monoclonal antibody. J.Immunol. 151 4306. PMID: 8409403.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Ac2-26 include:

Fredman et al (2015) Targeted nanoparticles containing the proresolving peptide Ac2-26 protect against advanced atherosclerosis in hypercholesterolemic mice. Sci Transl Med 7 275ra20. PMID: 25695999.

Leoni et al (2015) Human neutrophil formyl peptide receptor phosphorylation and the mucosal inflammatory response. Hum Mol Genet 97 87. PMID: 25395303.

Dalli et al (2012) Annexin A1 N-terminal derived Peptide ac2-26 exerts chemokinetic effects on human neutrophils. Front Pharmacol 3 28. PMID: 22403546.

Brancaleone et al (2011) Evidence for an anti-inflammatory loop centered on polymorphonuclear leukocyte formyl peptide receptor 2/lipoxin A4 receptor and operative in the inflamed microvasculature. J Immunol 186 4905. PMID: 21398608.

Do you know of a great paper that uses Ac2-26 from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Ac2-26, supplier, Annexin, lipocortin, 1-mimetic, inhibits, inhibitors, leukocyte, extravasation, Adhesion, Molecules, Tocris Bioscience, Cell Adhesion Molecule products

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