Cat. No. 1844
Biological ActivitySomatostatin receptor ligand (Ki values are 142, > 1000, 10.8, 16.6 and 5.7 nM for human cloned sst1 - 5 receptors respectively). Behaves as an antagonist on SRIF14-induced [35S]-GTPγS binding at sst3 and sst5 receptors (PKB values are 6.33 and 5.84 respectively).
(Modifications: Phe-1 = D-Phe, Trp-4 = D-Trp, X = D-Nal & C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Siehler and Hoyer (1999) Characterisation of human recombinant somatostatin receptors. Modulation of GTPgammaS binding. Naunyn Schmiedebergs Arch.Pharmacol. 360 500. PMID: 10598789.
Wilkinson et al (1996) Potent antagonism by BIM-23056 at the human recombinant somatostatin sst5 receptor. Br.J.Pharmacol. 118 445. PMID: 8762063.
Patel and Srikant (1994) Subtype selectivity of peptide analogs for all five cloned human somatostatin receptors (hsstr 1-5). Endocrinology 135 2814. PMID: 7988476.
Raynor et al (1993) Cloned somatostatin receptors: identification of subtype-selective peptides and demonstration of high affinity binding of linear peptides. Mol.Pharmacol. 43 838. PMID: 8100350.
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Keywords: BIM 23056, supplier, Somatostatin, receptor, agonists, Receptors, BIM23056, Tocris Bioscience, Somatostatin (sst) Receptor products
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