RHC 80267

Cat. No. 1842

RHC 80267 C20H34N4O4 [83654-05-1]

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Alternative Name: U 57908

Chemical Name: O,O'-[1,6-Hexanediylbis(iminocarbonyl)]dioxime cyclohexanone

Biological Activity

Inhibitor of diacylglycerol lipase (IC50 values are 1.1 and 4 μM in rat cardiac myocytes and canine platelets respectively). Weakly inhibits phospholipases C and A2. Potentiates acetylcholine evoked relaxation in mesenteric arteries by the inhibition of cholinesterase activity (IC50 = 4 μM).

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
>95 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Ghisdal et al (2005) The diacylglycerol lipase inhibitor RHC-80267 potentiates the relaxation to acetylcholine in rat mesenteric artery by anti-cholinesterase action. Eur.J.Pharmacol. 517 97. PMID: 15958263.

Suzuki et al (2002) Effects of RHC-80267, an inhibitor of diacylglycerol lipase, on excitation of circular smooth muscle of the guinea-pig gastric antrum. J.Smooth Muscle Res. 38 153. PMID: 12713022.

Sutherland and Amin (1982) Relative activities of rat and dog platelet phospholipase A2 and diglyceride lipase. J.Biol.Chem. 257 14006. PMID: 7142192.

If you know of a relevant reference for RHC 80267 please let us know.

Citations are publications that use Tocris products. Selected citations for RHC 80267 include:

Skinner et al (2013) Perilipin 1 moves between the fat droplet and the endoplasmic reticulum. Adipocyte 2 80. PMID: 23805403.

Li and Burrell (2011) Associative, bidirectional changes in neural signaling utilizing NMDA receptor- and endocannabinoid-dependent mechanisms. Learn Mem 18 545. PMID: 21844187.

Breunig et al (2010) The endocannabinoid 2-arachidonoyl-glycerol controls odor sensitivity in larvae of Xenopus laevis. Am J Physiol Gastrointest Liver Physiol 30 8965. PMID: 20592217.

Skinner et al (2009) Diacylglycerol enrichment of endoplasmic reticulum or lipid droplets recruits perilipin 3/TIP47 during lipid storage and mobilization. J Biol Chem 284 30941. PMID: 19748893.

Do you know of a great paper that uses RHC 80267 from Tocris? If so please let us know.show all ▼show less ▲

View Related Products by Product Action

Keywords: RHC 80267, supplier, Diacylglycerol, lipases, inhibitors, inhibits, PLC, PLA2, Phospholipases, C, A, Esterases, Lipid, Metabolism, DAGL, RHC80267, U57908, Tocris Bioscience, Other Lipid Metabolism Inhibitor products

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