Cat. No. 1836
Alternative Name: MK 678
Biological ActivityPeptide agonist for sst2 and sst5 somatostatin receptors. IC50/Kd values (nM) at cloned human somatostatin receptors are: > 1000 (sst1), 0.2 - 1.5 (sst2), 27 - 36 (sst3), > 127 (sst4), and 0.06 - 23 (sst5).
(Modifications: Ala-1 = N-methyl-Ala, Trp-3 = D-Trp, Cyclized)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Hannon et al (2002) Drug design at peptide receptors. Somatostatin receptor ligands. J.Mol.Neurosci. 18 15.
Hoyer et al (1994) Molecular pharmacology of somatostatin receptors. Naunyn Schmiedebergs Arch.Pharmacol. 350 441. PMID: 7870182.
Raynor et al (1993) Cloned somatostatin receptors: identification of subtype-selective peptides and demonstration of high affinity binding to linear peptides. Mol.Pharmacol. 43 838. PMID: 8100350.
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Keywords: Seglitide, supplier, sst2, sst5, agonists, Receptors, Somatostatin, MK678, Tocris Bioscience, Somatostatin (sst) Receptor Agonist products
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