Seglitide

Cat. No. 1836

Seglitide cyclo(N-methyl-Ala-Tyr-D-Trp-Lys-Val-Phe)

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Alternative Name: MK 678

Biological Activity

Peptide agonist for sst2 and sst5 somatostatin receptors. IC50/Kd values (nM) at cloned human somatostatin receptors are: > 1000 (sst1), 0.2 - 1.5 (sst2), 27 - 36 (sst3), > 127 (sst4), and 0.06 - 23 (sst5).

Technical Data

M.Wt:
808.98
Formula:
C44H56N8O7
Sequence:
AYWKVF

(Modifications: Ala-1 = N-methyl-Ala, Trp-3 = D-Trp, Cyclized)

Solubility:
Soluble to 1 mg/ml in 20% ethanol / water
Storage:
Desiccate at -20°C
CAS No:
81377-02-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Hannon et al (2002) Drug design at peptide receptors. Somatostatin receptor ligands. J.Mol.Neurosci. 18 15.

Hoyer et al (1994) Molecular pharmacology of somatostatin receptors. Naunyn Schmiedebergs Arch.Pharmacol. 350 441. PMID: 7870182.

Raynor et al (1993) Cloned somatostatin receptors: identification of subtype-selective peptides and demonstration of high affinity binding to linear peptides. Mol.Pharmacol. 43 838. PMID: 8100350.

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Keywords: Seglitide, supplier, sst2, sst5, agonists, Receptors, Somatostatin, MK678, Tocris Bioscience, Somatostatin (sst) Receptor Agonist products

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