HS 024

Cat. No. 1832

HS 024 Ac-Cys-Nle-Arg-His-D-Nal-Arg-Trp-Gly-Cys-NH2 (Disulfide bridge: 1 - 9)

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Biological Activity

Highly potent melanocortin MC4 receptor antagonist (Ki values are 0.29, 18.6, 5.45 and 3.29 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake, and blocks α-MSH- and MTII-induced hypotension and bradycardia in rats, following central administration in vivo.

Technical Data

M.Wt:
1266.5
Formula:
C58H79N19O10S2
Sequence:
CXRHXRWGC

(Modifications: Cys-1 = N-terminal Ac, X-2 = Nle, X-5 = Nal, Cys-9 = C-terminal amide, Disulfide bridge between 1 - 9)

Solubility:
Soluble to 0.50 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
212370-59-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Jonsson et al (2002) Food conversion is transiently affected during 4-week chronic administration of melanocortin agonist and antagonist in rats. J.Endocrinol. 173 517. PMID: 12065241.

Jonsson et al (2001) Melanocortin receptor agonist transiently increases oxygen consumption in rats. Neuroreport 12 3703. PMID: 11726778.

Kask et al (1998) Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist (HS024): evaluation in vitro and in vivo. Endocrinology 139 5006. PMID: 9832440.

If you know of a relevant reference for HS 024 please let us know.

Citations are publications that use Tocris products. Selected citations for HS 024 include:

Simamura et al (2015) Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via melanocortin receptors 1, 2 and 5. J Neurochem 10 e0123232. PMID: 25860801.

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Keywords: HS 024, supplier, potent, MC4R, receptor, antagonists, Receptors, Melanocortin, HS024, Tocris Bioscience, Melanocortin (MC) Receptor Antagonist products

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