Cat. No. 1821
Chemical Name: 4-(3-Chlorophenyl)-1,7-diethylpyrid
Biological ActivityOrally active PDE4 inhibitor (IC50 = 2.2 nM). Low emetogenic activity, suggested to be due to poor brain penetration.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Moriuchi et al (2003) Relaxant effect of YM976, a novel phosphodiesterase 4 inhibitor, on bovine tracheal smooth muscle. Eur.J.Pharmacol. 470 57. PMID: 12787831.
Aoki et al (2001) Studies on mechanisms of low emetogenicity of YM976, a novel phosphodiesterase type 4 inhibitor. J.Pharmacol.Exp.Ther. 298 1142. PMID: 11504812.
Aoki et al (2000) A novel phosphodiesterase type 4 inhibitor, YM976 (4-(3-chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one), with little emetogenic activity. J.Pharmacol.Exp.Ther. 295 255. PMID: 10991987.
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Keywords: YM 976, supplier, PDE4, inhibitors, inhibits, Phosphodiesterases, YM976, Tocris Bioscience, Phosphodiesterase Inhibitor products
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