Cat. No. 1821
Chemical Name: 4-(3-Chlorophenyl)-1,7-diethylpyrid
Biological ActivityOrally active PDE4 inhibitor (IC50 = 2.2 nM). Low emetogenic activity, suggested to be due to poor brain penetration.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Moriuchi et al (2003) Relaxant effect of YM976, a novel phosphodiesterase 4 inhibitor, on bovine tracheal smooth muscle. Eur.J.Pharmacol. 470 57. PMID: 12787831.
Aoki et al (2001) Studies on mechanisms of low emetogenicity of YM976, a novel phosphodiesterase type 4 inhibitor. J.Pharmacol.Exp.Ther. 298 1142. PMID: 11504812.
Aoki et al (2000) A novel phosphodiesterase type 4 inhibitor, YM976 (4-(3-chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one), with little emetogenic activity. J.Pharmacol.Exp.Ther. 295 255. PMID: 10991987.
If you know of a relevant reference for YM 976 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses YM 976 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: YM 976, supplier, PDE4, inhibitors, inhibits, Phosphodiesterases, YM976, Tocris Bioscience, Phosphodiesterase Inhibitor products
Find multiple products by catalog number
New Products in this Area
Potent and highly selective PDE5 inhibitor; orally bioavailable7-Ethoxyresorufin
Fluorometric CYP450 substrateGaleterone
CYP17 inhibitor; also androgen receptor antagonist
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.