Demethylasterriquinone B1

Cat. No. 1819

Demethylasterriquinone B1 C32H30N2O4 [78860-34-1]

Price and Availability

For Demethylasterriquinone B1 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Names: DAQ B1, L-783,281, DMAQ-B1

Chemical Name: 2-[2-(1,1-Dimethyl-2-propenyl)-1H-indol-3-yl]-3,6-dihydroxy-5-[7-(3-methyl-2-butenyl)-1H-indol-3-yl]-2,5-cyclohexadiene-1,4-dione

Biological Activity

Selective insulin receptor (IR) activator (EC50 values are 3 - 6 μM for IRTK and 100 μM for IGF1R and EGFR). Increases IR β subunit tyrosine phosphorylation and activation of PI 3-kinase and Akt, but not ERK. Induces glucose uptake in adipocytes and skeletal muscle in vitro, without enhancing vascular proliferation. Binds GAPDH. Also activates Trk by interacting at a site distinct from the neurotrophin-binding site.

Technical Data

M.Wt:
506.59
Formula:
C32H30N2O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
78860-34-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

Kim et al (2007) Glyceraldehyde 3-phosphate dehydrogenase is a cellular target of the insulin mimic demethylasterriquinone B1. J.Med.Chem. 50 3423. PMID: 17595071.

Webster et al (2003) Signaling effects of demethylasterriquinone B1, a selective insulin receptor modulator. Chembiochem 4 379. PMID: 12740809.

Salituro et al (2001) Discovery of a small molecule insulin receptor activator. Recent Prog.Horm.Res. 56 107. PMID: 11237209.

Wilkie et al (2001) The non-peptidyl fungal metabolite L-783,281 activates TRK neurotrophin receptors. J.Neurochem. 78 1135. PMID: 11553687.

Weber et al (2000) A novel insulin mimetic without a proliferative effect on vascular smooth muscle cells. J.Vasc.Surg. 32 1118. PMID: 11107083.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses Demethylasterriquinone B1 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Demethylasterriquinone B1, supplier, Selective, insulin, IRs, RTKs, activators, IGF, Receptors, Insulin-like, Receptor, Tyrosine, Kinases, DemethylasterriquinoneB1, DAQB1, L783281, Tocris Bioscience, Insulin and Insulin-like Receptors Activator products

Quick Order

Find multiple products by catalog number

divider line

Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Kinase Inhibitor Toolbox

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

divider line

Kinases Product Listing

Kinases Product Listing

Our Kinase listing highlights over 400 products for kinase research. Request copy or view PDF today.

divider line

Appetite Modulation

Written by S. Tucci et al

Peptides Involved in Appetite Modulation Scientific Review

Our Peptides Involved in Appetite Modulation review gives an overview of the peptides implicated in appetite regulation and energy homeostasis. View PDF today.

divider line

VEGF Pathway & Anti-Angiogenic Therapy

Written by N. Ferrara & Y. Crawford

Angiogenesis Life Science Poster

A summary of antiangiogenic therapies targeting the VEGF pathway and the mechanisms of therapy resistance. Request copy today.

divider line

Gut Hormones and the Regulation of Appetite

Written by V.J. Taylor et al

Gut Hormones Life Science Poster

Our Gut Hormones and the Regulation of Appetite poster gives an overview of the neuropeptide modulators and gut hormones that influence appetite. Request copy today.

divider line

Insulin Pathway

Insulin Signaling Pathway

Signals through the insulin pathway are fundamental for the regulation of intracellular glucose levels. View pathway or download PDF today.

divider line

New Products in this Area

HIOC

Selective TrkB receptor agonist; neuroprotectant

AV 412

Potent inhibitor of EGFR, ErbB2 and Abl receptor tyrosine kinases

CP 724714

Potent and selective ErbB2 inhibitor

Mitoglitazone

Insulin sensitizer; exhibits low binding affinity at PPARγ

PF 6274484

High affinity and potent covalent EGFR kinase inhibitor

Canertinib dihydrochloride

Potent EGFR kinase inhibitor

CHMFL-FLT3-122

Potent and selective FLT3 inhibitor

Sign-up for new product e-alerts
divider line

Bio-Techne Events

IVBM 2016

IVBM 2016

October 30 - November 3, 2016

Boston, MA, USA

Booth: 2