Cat. No. 1815
Alternative Name: PIA
Chemical Name: N-(1-Methylethyl)-hexadecanamide
Biological ActivityInhibitor of fatty acid amide hydrolase (FAAH); pIC50 = 4.89 for inhibition of [3H]-anandamide metabolism. Displays little binding to CB1 and CB2 receptors (IC50 > 100 μM) and very weakly blocks anandamide uptake (IC50 ~ 100 μM). Inhibits proliferation of C6 glioma cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Jonsson et al (2003) AM404 and VDM 11 non-specifically inhibit C6 glioma cell proliferation at concentrations used to block the cellular accumulation of the endocannabinoid anandamide. Arch.Toxicol. 77 201. PMID: 12698235.
Jonsson et al (2001) Effects of homologues and analogues of palmitoylethanolamide upon the inactivation of the endocannabinoid anandamide. Br.J.Pharmacol. 133 1263. PMID: 11498512.
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Citations are publications that use Tocris products.
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Keywords: Palmitoylisopropylamide, supplier, inhibitors, inhibits, FAAH, cannabinoids, Receptors, Anandamide, Amidase, Fatty, Acid, Amide, Hydrolases, Tocris Bioscience, Other Cannabinoid Inhibitor products
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Potent and selective CB2 partial agonist; orally biovailable
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