Y 134

Cat. No. 2676

Y 134 C28H28N2O3S [849662-80-2]

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Chemical Name: [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl]-[4-[4-(1-methylethyl)-1-piperazinyl]phenyl]methanone

Biological Activity

Selective estrogen receptor modulator (SERM) that displays selectivity for ERα over ERβ (Ki values are 0.09 and 11.31 nM respectively) and no cross-reactivity with mineralocorticoid, glucocorticoid, androgen and progesterone receptors. Acts as an agonist in the bone and antagonist in reproductive tissue. Suppresses estrogen-stimulated proliferation of ER-positive human breast cancer MCF-7 and T47D cells.

Technical Data

M.Wt:
472.6
Formula:
C28H28N2O3S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
849662-80-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Ning et al (2007) Biological activities of a novel selective oestrogen receptor modulator derived from raloxifene (Y134). Br.J.Pharmacol. 150 19. PMID: 17115070.

Yang et al (2005) Benzothiophenes containing a piperazine side chain as selective ligands for the estrogen receptor α and their bioactivities in vivo. Bioorg.Med.Chem.Lett. 15 1505. PMID: 15713417.

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View Related Products by Product Action

Keywords: Y 134, supplier, Selective, estrogen, receptor, modulators, SERM, selective, Erα, Eralpha, ERR, Estrogen, Receptors, Y134, Tocris Bioscience, Estrogen and Related Receptor Modulator products

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