Threo-methylphenidate hydrochloride

Cat. No. 1812

Threo-methylphenidate hydrochloride C14H19NO2.HCl [298-59-9]

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Alternative Name: Ritalin

Chemical Name: Threo-methyl α-Phenyl-2-piperidineacetate hydrochloride

Biological Activity

Psychomotor stimulant. Inhibitor of dopamine and noradrenalin transporters that increases the extracellular concentration of dopamine and noradrenalin. Increases locomotor activity in vivo.

Technical Data

M.Wt:
269.77
Formula:
C14H19NO2.HCl
Solubility:
Soluble to 50 mM in water and to 100 mM in ethanol
Purity:
>99 %
Storage:
Store at RT
CAS No:
298-59-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Askenasy et al (2007) Methylphenidate (Ritalin): behavioral studies in the rat. Int.J.Neurosci. 117 757. PMID: 17454243.

Leonard et al (2004) Methylphenidate: a review of its neuropharmacological, neuropsychological and adverse clinical effects. Human Psychopharm. 19 151.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Threo-methylphenidate hydrochloride include:

Poulin et al (2014) Fluoxetine blocks Nav1.5 channels via a mechanism similar to that of class 1 antiarrhythmics. Mol Pharmacol 86 378. PMID: 25028482.

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Keywords: Threo-methylphenidate hydrochloride, supplier, inhibitors, inhibits, dopamine, DAT, noradrenalin, noradrenaline, NET, adrenalin, transporters, Psychomotor, stimulants, neurotransmitter, Tocris Bioscience, Dopamine Transporter Inhibitor products

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