Cat. No. 1811

Modafinil C15H15NO2S [68693-11-8]

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Alternative Name: CRL 40476

Chemical Name: 2-[(Diphenylmethyl)sulfinyl]acetamide

Biological Activity

Psychostimulant that displays neuroprotective and antiparkinsonian activity in a primate model of Parkinson's disease. Promotes vigilence and wakefulness without the central and peripheral side effects associated with conventional dopaminergic psychostimulants. Mechanism of action is not fully understood, possibly via modulation of catecholamine/GABAergic neurotransmission.

Technical Data

Soluble to 75 mM in DMSO and to 10 mM in ethanol
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Madras et al (2006) Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro. J.Pharmacol.Exp.Ther. 319 561. PMID: 16885432.

Jenner et al (2000) Antiparkinsonian and neuroprotective effects of modafinil in the mtpt-treated common marmoset. Exp.Brain Res. 133 178. PMID: 10968218.

Ferraro et al (1997) Modafinil: an antinarcoleptic drug with a different neurochemical profile to d-amphetamine and dopamine uptake blockers. Biol.Psychiatry 42 1181. PMID: 9426889.

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Citations are publications that use Tocris products.

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View Related Products by Product Action

Keywords: Modafinil, supplier, Psychostimulant, Adrenergic, Compounds, Adrenoceptors, Receptors, Dopaminergic, Dopamine, GABA, CRL40476, Tocris Bioscience, Adrenergic Related products

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