Raclopride

Cat. No. 1810

Raclopride C15H20Cl2N2O3 [84225-95-6]

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Chemical Name: 3,5-Dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide

Biological Activity

Selective and potent dopamine D2/D3 receptor antagonist (Ki values are 1.8, 3.5, 2400 and 18000 nM for D2, D3, D4 and D1 receptors respectively). Centrally active following systemic administration in vivo.

Technical Data

M.Wt:
347.24
Formula:
C15H20Cl2N2O3
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
>99 %
Storage:
Store at RT
CAS No:
84225-95-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Seeman and Van Tol (1994) Dopamine receptor pharmacology. TiPS 15 264. PMID: 7940991.

Hall et al (1989) Animal pharmacology of raclopride, a selective dopamine D2 antagonist. Psychopharmacol.Ser. 7 123. PMID: 2687851.

Ogren et al (1986) The selective dopamine D2 receptor antagonist raclopride discriminates between dopamine-mediated motor functions. Psychopharmacology 90 287. PMID: 2947255.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Raclopride include:

Scardochio et al (2015) The Effects of Electrical and Optical Stimulation of Midbrain Dopaminergic Neurons on Rat 50-kHz Ultrasonic Vocalizations. Front Behav Neurosci 9 331. PMID: 26696851.

Chiodi et al (2014) Cocaine-induced changes of synaptic transmission in the striatum are modulated by adenosine A2A receptors and involve the tyrosine phosphatase STEP. Neuropsychopharmacology 39 569. PMID: 23989619.

Ahmadiantehrani and Ron (2013) Dopamine D2 receptor activation leads to an up-regulation of glial cell line-derived neurotrophic factor via Gβγ-Erk1/2-dependent induction of Zif268. J Neurochem. PMID: 23373701.

Ogata et al (2012) Dopamine and full-field illumination activate D1 and D2-D5-type receptors in adult rat retinal ganglion cells. J Comp Neurol 520 4032. PMID: 22678972.

Do you know of a great paper that uses Raclopride from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Raclopride, supplier, Potent, selective, D2/D3, antagonists, Dopamine, D2-like, Non-Selective, Receptors, dopaminergic, Tocris Bioscience, Non-selective Dopamine Antagonist products

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