Cat. No. 1810
Chemical Name: 3,5-Dichloro-N-[[(2S)-1-ethyl-2-pyr
Biological ActivitySelective and potent dopamine D2/D3 receptor antagonist (Ki values are 1.8, 3.5, 2400 and 18000 nM for D2, D3, D4 and D1 receptors respectively). Centrally active following systemic administration in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Seeman and Van Tol (1994) Dopamine receptor pharmacology. TiPS 15 264. PMID: 7940991.
Hall et al (1989) Animal pharmacology of raclopride, a selective dopamine D2 antagonist. Psychopharmacol.Ser. 7 123. PMID: 2687851.
Ogren et al (1986) The selective dopamine D2 receptor antagonist raclopride discriminates between dopamine-mediated motor functions. Psychopharmacology 90 287. PMID: 2947255.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for Raclopride include:
Scardochio et al (2015) The Effects of Electrical and Optical Stimulation of Midbrain Dopaminergic Neurons on Rat 50-kHz Ultrasonic Vocalizations. Front Behav Neurosci 9 331. PMID: 26696851.
Chiodi et al (2014) Cocaine-induced changes of synaptic transmission in the striatum are modulated by adenosine A2A receptors and involve the tyrosine phosphatase STEP. Neuropsychopharmacology 39 569. PMID: 23989619.
Ahmadiantehrani and Ron (2013) Dopamine D2 receptor activation leads to an up-regulation of glial cell line-derived neurotrophic factor via Gβγ-Erk1/2-dependent induction of Zif268. J Neurochem. PMID: 23373701.
Ogata et al (2012) Dopamine and full-field illumination activate D1 and D2-D5-type receptors in adult rat retinal ganglion cells. J Comp Neurol 520 4032. PMID: 22678972.
View Related Products by Target
View Related Products by Product Action
Keywords: Raclopride, supplier, Potent, selective, D2/D3, antagonists, Dopamine, D2-like, Non-Selective, Receptors, dopaminergic, Tocris Bioscience, Non-selective Dopamine Antagonist products