Altanserin hydrochloride

Cat. No. 1809

Altanserin hydrochloride C22H22FN3O2S.HCl [1135280-78-2]

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Chemical Name: 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4(1H)-quinazolinone hydrochloride

Biological Activity

Potent and selective 5-HT2A receptor antagonist (Ki values are 0.13, 4.55, 40, 62 and 1570 nM at 5-HT2A, α1, 5-HT2C, D2 and 5-HT1A respectively). Centrally active following systemic administration in vivo.

Technical Data

M.Wt:
447.95
Formula:
C22H22FN3O2S.HCl
Solubility:
Soluble to 20 mM in DMSO with gentle warming
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
1135280-78-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Herth et al (2009) Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET. Bioorg.Med.Chem. 17 2989. PMID: 19329329.

Kennett et al (1994) Evidence that 5-HT2C receptor antagonists are anxiolytic in the rat Geller-Seifter model of anxiety. Psychopharmacology 114 90. PMID: 7846211.

Koenig et al (1987) Stimulation of corticosterone and β-endorphin secretion in the rat by selective 5-HT receptor subtype activation. Eur.J.Pharmacol. 137 1. PMID: 2956114.

Sietnick (1985) Involvement of 5-HT2 receptors in the LSD- and L-5-HTP-induced suppression of lordotic behavior in the female rat. J.Neural Transm. 61 65. PMID: 3872342.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Altanserin hydrochloride include:

Yu and Yamaguchi (2009) 5-HT2C-like receptors in the brain of Xenopus laevis initiate sex-typical fictive vocalizations. J Neurophysiol 102 752. PMID: 19474172.

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Keywords: Altanserin hydrochloride, supplier, 5-HT2A, receptor, antagonists, Serotonin, Receptors, Tocris Bioscience, 5-HT2A Receptor Antagonist products

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