Decanoyl-RVKR-CMK

Cat. No. 3501

Decanoyl-RVKR-CMK Decanoyl-Arg-Val-Lys-Arg-chloromethyl ketone

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Biological Activity

Subtilisin/Kex2p-like proprotein convertase inhibitor; blocks activity of all seven convertases (PC1, PC2, PC4, PACE4, PC5, PC7 and furin). Abolishes proET-1 processing in endothelial cells; inhibits regulated secretion of the neuronal polypeptide VGF in PC12 cells.

Technical Data

M.Wt:
744.42
Formula:
C34H66ClN11O5
Sequence:
RVKR

(Modifications: Arg-1 = Decanoyl-Arg, Arg-4 = chlororomethylketone)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Store at -20°C
CAS No:
150113-99-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Tian and Jianhua (2010) Comparative study of the binding pocket of mammalian proprotein convertases and its implications for the design of specific small molecule inhibitors. Int.J.Biol.Sci. 6 89. PMID: 20151049.

Garcia et al (2005) A prohormone convertase cleavage site within a predicted alpha-helix mediates sorting of the neuronal and endocrine polypeptide VGF into the regulated secretory pathway. J.Biol.Chem. 280 41595. PMID: 16221685.

Denault et al (1995) Inhibition of convertase-related processing of proendothelin-1. J.Cardiovasc.Pharmacol. 26 S47. PMID: 8587448.

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Keywords: Decanoyl-RVKR-CMK, supplier, proprotein, convertases, inhibitors, inhibits, supplier, proteolytic, cleavage, calcium, dependent, serine, endopeptidases, furin, PC1, PC2, PC4, PACE4, PC5, PC7, secretory, pathway, Tocris Bioscience, Other Protease Inhibitor products

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