Granisetron hydrochloride

Cat. No. 2903

Granisetron hydrochloride C18H24N4O.HCl [107007-99-8]

Price and Availability

For Granisetron hydrochloride pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: BRL 43694

Chemical Name: 1-Methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide hydrochloride

Biological Activity

5-HT3 receptor antagonist that possesses potent antiemetic activity.

Technical Data

M.Wt:
348.87
Formula:
C18H24N4O.HCl
Solubility:
Soluble to 100 mM in water and to 10 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
107007-99-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

Martin et al (1998) Anti-emetic effect of Ondansetron and Granisetron after exposure to mixed neutron and gamma irradiation. Rad.Res. 149 631.

Plosker and Goa (1991) Granisetron. A review of its pharmacological properties and therapeutic use as an antiemetic. Drugs 42 805. PMID: 1723376.

Sanger and Nelson (1989) Selective and functional 5-hydroxytryptamine3 receptor antagonism by BRL 43694 (granisetron). Eur.J.Pharmacol. 159 113. PMID: 2540014.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Granisetron hydrochloride include:

Gerhold et al (2015) Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci 35 9580. PMID: 26134641.

Do you know of a great paper that uses Granisetron hydrochloride from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Granisetron hydrochloride, supplier, 5-HT3, antagonists, Serotonin, Receptors, BRL43694, Tocris Bioscience, 5-HT3 Receptor Antagonist products

Quick Order

Find multiple products by catalog number

divider line

5-HT Review

Written by N. Barnes & J. Neumaler

5-HT Receptors Scientific Review

Our 5-HT review summarizes the serotonin receptor subtypes and highlights their importance in mediating various physiological & pharmacological processes. Request copy or view PDF today.

divider line

Bio-Techne Events

Neuroscience 2016

Neuroscience 2016

November 12 - 16, 2016

San Diego, CA, USA

Booth: 3217