Cat. No. 2903
Alternative Name: BRL 43694
Chemical Name: 1-Methyl-N-[(3-endo)-9-methyl-9-aza
Biological Activity5-HT3 receptor antagonist that possesses potent antiemetic activity.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Martin et al (1998) Anti-emetic effect of Ondansetron and Granisetron after exposure to mixed neutron and gamma irradiation. Rad.Res. 149 631.
Plosker and Goa (1991) Granisetron. A review of its pharmacological properties and therapeutic use as an antiemetic. Drugs 42 805. PMID: 1723376.
Sanger and Nelson (1989) Selective and functional 5-hydroxytryptamine3 receptor antagonism by BRL 43694 (granisetron). Eur.J.Pharmacol. 159 113. PMID: 2540014.
If you know of a relevant reference for Granisetron hydrochloride please let us know.
Citations are publications that use Tocris products. Selected citations for Granisetron hydrochloride include:
Gerhold et al (2015) Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci 35 9580. PMID: 26134641.
Otvos et al (2015) Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms. Neuropharmacology 7 2336. PMID: 26114334.
Do you know of a great paper that uses Granisetron hydrochloride from Tocris? If so please let us know.
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Keywords: Granisetron hydrochloride, supplier, 5-HT3, antagonists, Serotonin, Receptors, BRL43694, Tocris Bioscience, 5-HT3 Receptor Antagonist products
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June 14 - 17, 2017
Boston, MA, USA