UCB 35625

Cat. No. 2757

UCB 35625 C30H37Cl2IN2O2

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Chemical Name: 1,4-trans-1-(1-Cycloocten-1-ylmethyl)-4-[[(2,7-dichloro-9H-xanthen-9-yl)carbonyl]amino]-1-ethylpiperidinium iodide

Biological Activity

Potent chemokine CCR1 and CCR3 receptor antagonist. Inhibits MIP-1α-induced chemotaxis in CCR1 transfectants and eotaxin-induced chemotaxis in CCR3 transfectants (IC50 values are 9.57 and 93.8 nM respectively). Antagonizes CCR3-mediated entry of HIV-1 isolate 89.6 into NP-2 cells (IC50 = 57 nM). Isomer of J 113863 (Cat. No. 2595).

Technical Data

M.Wt:
655.44
Formula:
C30H37Cl2IN2O2
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Lopes de Mendonca et al (2005) Site-directed mutagenesis of CC chemokine receptor 1 reveals the mechanism of action of UCB 35625, a small molecule chemokine receptor antagonist. J.Biol.Chem. 280 4808. PMID: 15548526.

Sabroe et al (2000) A small molecule antagonist of chemokine receptors CCR1 and CCR3. J.Biol.Chem. 275 25985. PMID: 10854442.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for UCB 35625 include:

Liu et al (2016) Cancer-associated fibroblasts promote hepatocellular carcinoma metastasis through chemokine-activated hedgehog and TGF-β pathways. Cancer Lett. 379 49. PMID: 27216982 .

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Keywords: UCB 35625, supplier, Potent, CCR1, CCR3, antagonists, Chemokine, Receptors, UCB35625, Rantes, Tocris Bioscience, Chemokine CC Receptor Antagonist products

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